DegronMD

Uniprot ID: P22681

Source protein: E3 ubiquitin-protein ligase CBL

Source gene: CBL

Class: DEG_APCC_DBOX_1

Location: 786:794

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9905

ASA_SCORE: 70.0111

COIL: 0.6172

CONS_SCORE: 0.3526

DSS_SCORE: 0.422

HELIX: 0.346

FCONS_SCORE: 1.0941

RIG_SCORE: 0.7724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S798Y	TCGA-55-8620	LUAD	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.S798Y	TCGA-ZF-AA4X	BLCA	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.S798Y	DO219091	BLCA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.S798Y	DO24547	LUAD	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.R788Q	TCGA-AG-A002	READ	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.6218
p.S794Y	TCGA-AX-A2HD	UCEC	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.712
p.S794Y	DO42608	UCEC	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.712
p.A786G	TCGA-KK-A8IK	PRAD	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.6429
p.A786G	DO219339	PRAD	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.6429
p.N795I	TCGA-L5-A8NI	ESCA	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	0.3056
p.P782L	DO229054	LICA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.P782L	SIDM00309	Mesothelioma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2222
p.V784M	DO35083	PACA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2778
p.V784M	SIDM01088	Endometrial Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	0.2778
p.V784M	ACH-000965	Endometrial/Uterine Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.2778
p.D792H	SIDM00791	Chronic Myelogenous Leukemia	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	0.6577
p.D792H	ACH-000551	Leukemia	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.6577
p.D792H	ACH-002061	Leukemia	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.6577
p.D792H	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	ARRTLSDIS	DEG_APCC_DBOX_1	0.6577
p.N795T	SIDM01450	Gastric Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	0.3056
p.N795T	ACH-000898	Gastric Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.3056
p.S794F	SIDM00173	Head and Neck Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	0.7982
p.S794F	ACH-000618	Head and Neck Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.7982
p.V784L	ACH-000951	Lung Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.2778
p.R787S	ACH-001852	Bile Duct Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	0.7427
p.A804V	HEC-1	endometrium	COSMIC	ARRTLSDIS	DEG_APCC_DBOX_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARRTLSDIS

Degron related mutations and impact score

Drug responses associated with CBL mutations

All proteins holding degron of ARRTLSDIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22681	E3 ubiquitin-protein ligase CBL	DEG_APCC_DBOX_1	786:794	ARRTLSDIS	APC,CDC20,FZR1	0.9905	More...