DegronMD - P22681(CBL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S798Y	TCGA-55-8620	LUAD	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.S798Y	TCGA-ZF-AA4X	BLCA	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.S798Y	DO219091	BLCA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.S798Y	DO24547	LUAD	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.P566H	TCGA-85-7950	LUSC	TCGA	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.1111
p.P566H	DO26878	LUSC	ICGC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.1111
p.G342E	TCGA-A5-A0G2	UCEC	TCGA	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation rewiring degron network	0.3056
p.G342E	DO41235	UCEC	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation rewiring degron network	0.3056
p.R788Q	TCGA-AG-A002	READ	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6218
p.R343Q	TCGA-AN-A046	BRCA	TCGA	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation rewiring degron network	0.2778
p.R343Q	DO1285	BRCA	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation rewiring degron network	0.2778
p.S794Y	TCGA-AX-A2HD	UCEC	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.712
p.S794Y	DO42608	UCEC	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.712
p.F336L	TCGA-EO-A22U	UCEC	TCGA	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation altering degron motif	0.587
p.F336L	DO43755	UCEC	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation altering degron motif	0.587
p.P596T	TCGA-H4-A2HO	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1667
p.P596T	DO494	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1667
p.A786G	TCGA-KK-A8IK	PRAD	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6429
p.A786G	DO219339	PRAD	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6429
p.N795I	TCGA-L5-A8NI	ESCA	TCGA	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.3056
p.Y337C	DO233011	GACA	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation altering degron motif	0.5976
p.R593W	DO233268	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.0833
p.R593W	DO51061	PRAD	ICGC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.0833
p.P340L	DO228924	LICA	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation altering degron motif	0.6471
p.D341Y	DO229035	LICA	ICGC	FYLFPD	LIG_APCC_ABBA_1	336:341	Mutation altering degron motif	0.7325
p.P782L	DO229054	LICA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.P782L	SIDM00309	Mesothelioma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2222
p.L614S	DO220895	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1111
p.V784M	DO35083	PACA	ICGC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2778
p.V784M	SIDM01088	Endometrial Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2778
p.V784M	ACH-000965	Endometrial/Uterine Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2778
p.P569A	SIDM02059	Colorectal Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.1944
p.D792H	SIDM00791	Chronic Myelogenous Leukemia	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6577
p.D792H	ACH-000551	Leukemia	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6577
p.D792H	ACH-002061	Leukemia	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6577
p.D792H	K-562	haematopoietic and lymphoid tissue	COSMIC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.6577
p.D576N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation altering degron motif	0.5821
p.D576N	ACH-002256	Leukemia	CCLE	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation altering degron motif	0.5821
p.D576N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation altering degron motif	0.5821
p.S584G	SIDM00102	Mesothelioma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation blocking phosphorylation signal	0.7222
p.S584G	ACH-002125	Lung Cancer	CCLE	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation blocking phosphorylation signal	0.7222
p.S584G	H2461	pleura	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation blocking phosphorylation signal	0.7222
p.K597R	SIDM00292	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation substituting flanking lysine	0.3056
p.K597R	ACH-002077	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	602:606	Mutation substituting flanking lysine	0.3056
p.K597R	LU-165	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	602:606	Mutation substituting flanking lysine	0.3056
p.R585C	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.25
p.R585C	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.25
p.R585C	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.25
p.R585C	A549	lung	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	574:582	Mutation rewiring degron network	0.25
p.N795T	SIDM01450	Gastric Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.3056
p.N795T	ACH-000898	Gastric Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.3056
p.S794F	SIDM00173	Head and Neck Carcinoma	GDSC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.7982
p.S794F	ACH-000618	Head and Neck Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.7982
p.V784L	ACH-000951	Lung Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation rewiring degron network	0.2778
p.R787S	ACH-001852	Bile Duct Cancer	CCLE	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation altering degron motif	0.7427
p.A804V	HEC-1	endometrium	COSMIC	ARRTLSDIS	DEG_APCC_DBOX_1	786:794	Mutation blocking phosphorylation signal	0.5

Kaplan plot for CBL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBL

UniProt ID: P22681

Entrez ID: 867

Protein name: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBL in