DegronMD

Uniprot ID: P22681

Source protein: E3 ubiquitin-protein ligase CBL

Source gene: CBL

Class: LIG_APCC_ABBA_1

Location: 336:341

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8674

ASA_SCORE: 39.7833

COIL: 0.7168

CONS_SCORE: 0.818

DSS_SCORE: 0.366

HELIX: 0.0333

FCONS_SCORE: 1.1631

RIG_SCORE: 0.8039

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G342E	TCGA-A5-A0G2	UCEC	TCGA	FYLFPD	LIG_APCC_ABBA_1	0.3056
p.G342E	DO41235	UCEC	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.3056
p.R343Q	TCGA-AN-A046	BRCA	TCGA	FYLFPD	LIG_APCC_ABBA_1	0.2778
p.R343Q	DO1285	BRCA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.2778
p.F336L	TCGA-EO-A22U	UCEC	TCGA	FYLFPD	LIG_APCC_ABBA_1	0.587
p.F336L	DO43755	UCEC	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.587
p.Y337C	DO233011	GACA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.5976
p.P340L	DO228924	LICA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.6471
p.D341Y	DO229035	LICA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22681	E3 ubiquitin-protein ligase CBL	LIG_APCC_ABBA_1	336:341	FYLFPD	APC,CDC20,FZR1	0.8674	More...
Q12891	Hyaluronidase-2	LIG_APCC_ABBA_1	205:210	FYLFPD	APC,CDC20,FZR1	0.5779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons