DegronMD

Uniprot ID: Q12891

Source protein: Hyaluronidase-2

Source gene: HYAL2

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5779

ASA_SCORE: 10.5333

COIL: 0.5307

CONS_SCORE: 0.8114

DSS_SCORE: 0.0149

HELIX: 0.064

FCONS_SCORE: 1.3484

RIG_SCORE: 0.9298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P209L	TCGA-B5-A1MX	UCEC	TCGA	FYLFPD	LIG_APCC_ABBA_1	0.6471
p.P209L	DO41999	UCEC	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.6471
p.R198Q	TCGA-B6-A0RP	BRCA	TCGA	FYLFPD	LIG_APCC_ABBA_1	0.1389
p.R198Q	DO2581	BRCA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.1389
p.R198L	DO232030	LICA	ICGC	FYLFPD	LIG_APCC_ABBA_1	0.1389
p.D210N	SIDM01958	Esophageal Carcinoma	GDSC	FYLFPD	LIG_APCC_ABBA_1	0.6932
p.P199L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	FYLFPD	LIG_APCC_ABBA_1	0.1667
p.P199L	ACH-000964	Leukemia	CCLE	FYLFPD	LIG_APCC_ABBA_1	0.1667
p.D215E	SIDM01770	Gastric Carcinoma	GDSC	FYLFPD	LIG_APCC_ABBA_1	0.1944
p.D215E	ACH-000908	Gastric Cancer	CCLE	FYLFPD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22681	E3 ubiquitin-protein ligase CBL	LIG_APCC_ABBA_1	336:341	FYLFPD	APC,CDC20,FZR1	0.8674	More...
Q12891	Hyaluronidase-2	LIG_APCC_ABBA_1	205:210	FYLFPD	APC,CDC20,FZR1	0.5779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons