DegronMD

Uniprot ID: P22681

Source protein: E3 ubiquitin-protein ligase CBL

Source gene: CBL

Class: DEG_APCC_DBOX_1

Location: 574:582

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9905

ASA_SCORE: 94.5333

COIL: 0.9348

CONS_SCORE: 0.317

DSS_SCORE: 0.642

HELIX: 0.0401

FCONS_SCORE: 1.0178

RIG_SCORE: 0.6375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P566H	TCGA-85-7950	LUSC	TCGA	SRDKLPPVP	DEG_APCC_DBOX_1	0.1111
p.P566H	DO26878	LUSC	ICGC	SRDKLPPVP	DEG_APCC_DBOX_1	0.1111
p.P569A	SIDM02059	Colorectal Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.1944
p.D576N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.5821
p.D576N	ACH-002256	Leukemia	CCLE	SRDKLPPVP	DEG_APCC_DBOX_1	0.5821
p.D576N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	0.5821
p.S584G	SIDM00102	Mesothelioma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.7222
p.S584G	ACH-002125	Lung Cancer	CCLE	SRDKLPPVP	DEG_APCC_DBOX_1	0.7222
p.S584G	H2461	pleura	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	0.7222
p.R585C	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.25
p.R585C	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.25
p.R585C	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	SRDKLPPVP	DEG_APCC_DBOX_1	0.25
p.R585C	A549	lung	COSMIC	SRDKLPPVP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22681	E3 ubiquitin-protein ligase CBL	DEG_APCC_DBOX_1	574:582	SRDKLPPVP	APC,CDC20,FZR1	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons