DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_APCC_DBOX_1

Location: 1039:1047

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5902

ASA_SCORE: 86.5222

COIL: 0.3436

CONS_SCORE: 0.3327

DSS_SCORE: 0.3311

HELIX: 0.6476

FCONS_SCORE: 0.8128

RIG_SCORE: 0.7978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1056I	TCGA-46-3769	LUSC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	0.0833
p.S1056I	DO26590	LUSC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.0833
p.M1036V	TCGA-BS-A0V8	UCEC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	0.25
p.M1036V	DO42240	UCEC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.25
p.S1032C	TCGA-D7-8573	STAD	TCGA	ARSALALLA	DEG_APCC_DBOX_1	0.5833
p.S1032C	DO48001	STAD	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.5833
p.A1042T	TCGA-DF-A2KU	UCEC	TCGA	ARSALALLA	DEG_APCC_DBOX_1	0.6028
p.A1042T	DO223286	UCEC	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.6028
p.L1043F	TCGA-ZG-A9N3	PRAD	TCGA	ARSALALLA	DEG_APCC_DBOX_1	0.6981
p.L1043F	DO219446	PRAD	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.6981
p.G1029S	DO52146	PAEN	ICGC	ARSALALLA	DEG_APCC_DBOX_1	0.0556
p.V1034M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ARSALALLA	DEG_APCC_DBOX_1	0.1944
p.V1034M	ACH-000920	Leukemia	CCLE	ARSALALLA	DEG_APCC_DBOX_1	0.1944
p.V1034M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	0.1944
p.S1056G	SIDM00690	Head and Neck Carcinoma	GDSC	ARSALALLA	DEG_APCC_DBOX_1	0.0833
p.A1042V	SIDM01682	Gastric Carcinoma	GDSC	ARSALALLA	DEG_APCC_DBOX_1	0.5825
p.A1042V	ACH-000110	Gastric Cancer	CCLE	ARSALALLA	DEG_APCC_DBOX_1	0.5825
p.T1047A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	0.7139
p.A1030T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSALALLA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR3	Glutamine and serine-rich protein 1	DEG_APCC_DBOX_1	1039:1047	ARSALALLA	APC,CDC20,FZR1	0.5902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons