DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ARSHLRQMG
Uniprot ID:
O95785
Source protein:
Protein Wiz
Source gene:
WIZ
Class:
DEG_APCC_DBOX_1
Location:
1062:1070
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9294
ASA_SCORE:
74.5222
COIL:
0.4744
CONS_SCORE:
0.7995
DSS_SCORE:
0.3076
HELIX:
0.441
FCONS_SCORE:
1
RIG_SCORE:
0.7306
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1064P
ACH-000937
Leukemia
CCLE
ARSHLRQMG
DEG_APCC_DBOX_1
0.6752
Drug responses associated with WIZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARSHLRQMG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95785
Protein Wiz
DEG_APCC_DBOX_1
1062:1070
ARSHLRQMG
APC,CDC20,FZR1
0.9294
More...
O95785
Protein Wiz
DEG_APCC_DBOX_1
1246:1254
ARSHLRQMG
APC,CDC20,FZR1
0.9594
More...