DegronMD

Uniprot ID: O95785

Source protein: Protein Wiz

Source gene: WIZ

Class: DEG_APCC_DBOX_1

Location: 1246:1254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9594

ASA_SCORE: 76.7778

COIL: 0.4869

CONS_SCORE: 0.793

DSS_SCORE: 0.3544

HELIX: 0.4082

FCONS_SCORE: 1.013

RIG_SCORE: 0.7209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1237T	LIM1215	large_intestine	COSMIC	ARSHLRQMG	DEG_APCC_DBOX_1	0.0833
p.P1239A	SKN	soft_tissue	COSMIC	ARSHLRQMG	DEG_APCC_DBOX_1	0.1389
p.L1238R	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	ARSHLRQMG	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons