DegronMD

Uniprot ID: Q9Y4D7

Source protein: Plexin-D1

Source gene: PLXND1

Class: DEG_APCC_DBOX_1

Location: 314:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7072

ASA_SCORE: 23.0111

COIL: 0.2141

CONS_SCORE: 0.5094

DSS_SCORE: 0.2849

HELIX: 0.0617

FCONS_SCORE: 1.5637

RIG_SCORE: 0.8051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P324S	DO222874	COCA	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	0.2778
p.P324S	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	0.2778
p.D330N	DO227531	PACA	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	0.1111
p.D330A	DO48573	PAEN	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	0.1111
p.A319T	ACH-000597	Rhabdoid	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	0.6028
p.A319T	ACH-001200	Rhabdoid	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	0.6028
p.H325Q	ACH-000776	Brain Cancer	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	0.25
p.H325Q	ACH-002066	Sarcoma	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D7	Plexin-D1	DEG_APCC_DBOX_1	314:322	ARSLLARIC	APC,CDC20,FZR1	0.7072	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons