DegronMD - Q9Y4D7(PLXND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V763M	TCGA-76-6280	GBM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.2778
p.V763M	DO11890	GBM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.2778
p.R1169H	TCGA-AG-A002	READ	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.7133
p.R1169H	TCGA-CV-5441	HNSC	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.7133
p.R1169H	DO15671	HNSC	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.7133
p.P762H	TCGA-DA-A1IB	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.3056
p.P762H	DO38033	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.3056
p.G766C	TCGA-EB-A299	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.1944
p.G766C	DO37794	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.1944
p.L760M	TCGA-GN-A265	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation altering degron motif	0.5999
p.L760M	DO37491	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation altering degron motif	0.5999
p.P1174H	TCGA-VQ-A91D	STAD	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.6583
p.P1174H	DO51783	STAD	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.6583
p.T1180M	TCGA-VQ-A91K	STAD	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1667
p.T1180M	DO51785	STAD	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1667
p.S743P	DO52605	BOCA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.0556
p.P324S	DO222874	COCA	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.2778
p.P324S	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.2778
p.T747M	DO233884	GACA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.1667
p.T747M	SIDM00068	Colorectal Carcinoma	GDSC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.1667
p.T747M	GEO	large intestine	COSMIC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.1667
p.D1158E	DO228948	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1111
p.T1180S	DO228860	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1667
p.P753H	DO228974	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation altering degron motif	0.6583
p.N770K	DO229015	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.0833
p.L756M	DO229024	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation altering degron motif	0.5999
p.A761E	DO229031	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation altering degron motif	0.659
p.P764T	DO229036	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.25
p.T1180K	DO229035	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1667
p.P1159L	DO222843	MELA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.1389
p.P744L	DO232838	NACA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	753:761	Mutation rewiring degron network	0.0833
p.D330N	DO227531	PACA	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1111
p.D330A	DO48573	PAEN	ICGC	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1111
p.R1183W	SIDM00541	Colorectal Carcinoma	GDSC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.0833
p.R1183W	ACH-000926	Colon/Colorectal Cancer	CCLE	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.0833
p.R1183W	HT55	large intestine	COSMIC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation rewiring degron network	0.0833
p.Y1172C	SIDM00789	Colorectal Carcinoma	GDSC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.5976
p.Y1172C	ACH-000997	Colon/Colorectal Cancer	CCLE	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.5976
p.Y1172C	HCT-15	large intestine	COSMIC	SRFRLDYLP	DEG_APCC_DBOX_1	1166:1174	Mutation altering degron motif	0.5976
p.A319T	ACH-000597	Rhabdoid	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6028
p.A319T	ACH-001200	Rhabdoid	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6028
p.H325Q	ACH-000776	Brain Cancer	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.H325Q	ACH-002066	Sarcoma	CCLE	ARSLLARIC	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25

Kaplan plot for PLXND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXND1

UniProt ID: Q9Y4D7

Entrez ID: 23129

Protein name: Plexin-D1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXND1 in