DegronMD

Uniprot ID: Q9Y4D7

Source protein: Plexin-D1

Source gene: PLXND1

Class: DEG_APCC_DBOX_1

Location: 753:761

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6164

ASA_SCORE: 72.0111

COIL: 0.7818

CONS_SCORE: 0.3742

DSS_SCORE: 0.4849

HELIX: 0.0279

FCONS_SCORE: 1.0917

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V763M	TCGA-76-6280	GBM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	0.2778
p.V763M	DO11890	GBM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.2778
p.P762H	TCGA-DA-A1IB	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	0.3056
p.P762H	DO38033	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.3056
p.G766C	TCGA-EB-A299	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	0.1944
p.G766C	DO37794	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.1944
p.L760M	TCGA-GN-A265	SKCM	TCGA	PRTLLSPLA	DEG_APCC_DBOX_1	0.5999
p.L760M	DO37491	SKCM	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.5999
p.S743P	DO52605	BOCA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.0556
p.T747M	DO233884	GACA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.1667
p.T747M	SIDM00068	Colorectal Carcinoma	GDSC	PRTLLSPLA	DEG_APCC_DBOX_1	0.1667
p.T747M	GEO	large_intestine	COSMIC	PRTLLSPLA	DEG_APCC_DBOX_1	0.1667
p.P753H	DO228974	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.6583
p.N770K	DO229015	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.0833
p.L756M	DO229024	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.5999
p.A761E	DO229031	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.659
p.P764T	DO229036	LICA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.25
p.P744L	DO232838	NACA	ICGC	PRTLLSPLA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D7	Plexin-D1	DEG_APCC_DBOX_1	753:761	PRTLLSPLA	APC,CDC20,FZR1	0.6164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons