DegronMD

Uniprot ID: Q9Y4D7

Source protein: Plexin-D1

Source gene: PLXND1

Class: DEG_APCC_DBOX_1

Location: 1166:1174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6175

ASA_SCORE: 54.2333

COIL: 0.5209

CONS_SCORE: 0.36

DSS_SCORE: 0.4588

HELIX: 0.0408

FCONS_SCORE: 0.9678

RIG_SCORE: 0.7639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1169H	TCGA-AG-A002	READ	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	0.7133
p.R1169H	TCGA-CV-5441	HNSC	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	0.7133
p.R1169H	DO15671	HNSC	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.7133
p.P1174H	TCGA-VQ-A91D	STAD	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	0.6583
p.P1174H	DO51783	STAD	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.6583
p.T1180M	TCGA-VQ-A91K	STAD	TCGA	SRFRLDYLP	DEG_APCC_DBOX_1	0.1667
p.T1180M	DO51785	STAD	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.1667
p.D1158E	DO228948	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.1111
p.T1180S	DO228860	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.1667
p.T1180K	DO229035	LICA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.1667
p.P1159L	DO222843	MELA	ICGC	SRFRLDYLP	DEG_APCC_DBOX_1	0.1389
p.R1183W	SIDM00541	Colorectal Carcinoma	GDSC	SRFRLDYLP	DEG_APCC_DBOX_1	0.0833
p.R1183W	ACH-000926	Colon/Colorectal Cancer	CCLE	SRFRLDYLP	DEG_APCC_DBOX_1	0.0833
p.R1183W	HT55	large_intestine	COSMIC	SRFRLDYLP	DEG_APCC_DBOX_1	0.0833
p.Y1172C	SIDM00789	Colorectal Carcinoma	GDSC	SRFRLDYLP	DEG_APCC_DBOX_1	0.5976
p.Y1172C	ACH-000997	Colon/Colorectal Cancer	CCLE	SRFRLDYLP	DEG_APCC_DBOX_1	0.5976
p.Y1172C	HCT-15	large_intestine	COSMIC	SRFRLDYLP	DEG_APCC_DBOX_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D7	Plexin-D1	DEG_APCC_DBOX_1	1166:1174	SRFRLDYLP	APC,CDC20,FZR1	0.6175	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons