DegronMD

Uniprot ID: Q8TES7

Source protein: Fas-binding factor 1

Source gene: FBF1

Class: DEG_APCC_DBOX_1

Location: 237:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9905

ASA_SCORE: 66.5778

COIL: 0.4021

CONS_SCORE: 0.5277

DSS_SCORE: 0.6545

HELIX: 0.5687

FCONS_SCORE: 1.2733

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E243Q	TCGA-90-7964	LUSC	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	0.5633
p.E243Q	DO27046	LUSC	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.5633
p.R235C	TCGA-C8-A26Y	BRCA	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	0.2778
p.R235C	DO1273	BRCA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.2778
p.R235C	ACH-000845	Lung Cancer	CCLE	ARSTLDELL	DEG_APCC_DBOX_1	0.2778
p.T240M	TCGA-D1-A1NS	UCEC	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	0.6312
p.T240M	DO42193	UCEC	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.6312
p.P236H	TCGA-G7-6793	KIRP	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	0.3056
p.P236H	DO20835	KIRP	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.3056
p.R235H	DO230323	COCA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.2778
p.R235H	DO233764	GACA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	0.2778
p.G243E	SIDM00541	Colorectal Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	0.7199
p.G243E	HT55	large_intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.7199
p.D244Y	SIDM01097	Other Solid Cancers	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	0.7325
p.D244Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.7325
p.S253F	SIDM00309	Mesothelioma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	0.1111
p.S253F	SIDM00032	Bladder Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	0.1111
p.R249C	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	0.2222
p.G229E	ACH-000926	Colon/Colorectal Cancer	CCLE	ARSTLDELL	DEG_APCC_DBOX_1	0.1111
p.G229E	HT55	large_intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.1111
p.G242E	HT55	large_intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.7199
p.D243Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.7325
p.D230Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TES7	Fas-binding factor 1	DEG_APCC_DBOX_1	237:245	ARSTLDELL	APC,CDC20,FZR1	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons