DegronMD - Q8TES7(FBF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E243Q	TCGA-90-7964	LUSC	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.5633
p.E243Q	DO27046	LUSC	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.5633
p.E202K	TCGA-AF-2687	READ	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.1389
p.E202K	DO36902	READ	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.1389
p.R198Q	TCGA-AP-A056	UCEC	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.25
p.R198Q	DO234183	ESAD	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.25
p.R198Q	DO43971	UCEC	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.25
p.R198Q	SiHa	cervix	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.25
p.A474D	TCGA-AP-A059	UCEC	TCGA	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.R235C	TCGA-C8-A26Y	BRCA	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.R235C	DO1273	BRCA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.R235C	ACH-000845	Lung Cancer	CCLE	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.T240M	TCGA-D1-A1NS	UCEC	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6312
p.T240M	DO42193	UCEC	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6312
p.G468R	TCGA-DD-A1EC	LIHC	TCGA	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.P178H	TCGA-ER-A1A1	SKCM	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.P178H	TCGA-G2-A2EJ	BLCA	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.P178H	DO554	BLCA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.P178H	DO37413	SKCM	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.P236H	TCGA-G7-6793	KIRP	TCGA	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.P236H	DO20835	KIRP	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.G193V	TCGA-SJ-A6ZI	UCEC	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.6421
p.G193V	DO219784	UCEC	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.6421
p.R235H	DO230323	COCA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.R235H	DO233764	GACA	ICGC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.A473E	DO228952	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.T180K	DO228952	LICA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation blocking phosphorylation signal	0.5556
p.P457H	DO229028	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.S459Y	DO229027	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.P189T	DO229035	LICA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.5919
p.T465N	DO229037	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7055
p.G469R	DO22982	LIHC	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.P457S	DO229453	SKCA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.H456N	DO229216	THCA	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.S187P	DO229211	THCA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.3056
p.A475D	DO41361	UCEC	ICGC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1111
p.G243E	SIDM00541	Colorectal Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7199
p.G243E	HT55	large intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7199
p.P179S	SIDM00107	Melanoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.P179S	UACC-62	skin	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.G469V	SIDM00087	Plasma Cell Myeloma	GDSC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.D244Y	SIDM01097	Other Solid Cancers	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7325
p.D244Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7325
p.P179L	SIDM00014	Colorectal Carcinoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.P179L	SIDM00683	Prostate Carcinoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.P179L	LIM1215	large intestine	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.P179L	LNCaP-Clone-FGC	prostate	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0833
p.S253F	SIDM00309	Mesothelioma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.S253F	SIDM00032	Bladder Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.R249C	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2222
p.Q184P	ACH-000484	Kidney Cancer	CCLE	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.2222
p.A473T	ACH-000816	Lung Cancer	CCLE	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.A473T	NCI-H524	lung	COSMIC	PLTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.G229E	ACH-000926	Colon/Colorectal Cancer	CCLE	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229E	HT55	large intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.L203S	ACH-000981	Leukemia	CCLE	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.1111
p.G242E	HT55	large intestine	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7199
p.P178L	LNCaP-Clone-FGC	prostate	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.P178L	LIM1215	large intestine	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.D243Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7325
p.P178S	UACC-62	skin	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.D230Y	SK-PN-DW	bone	COSMIC	ARSTLDELL	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBF1

UniProt ID: Q8TES7

Entrez ID: 85302

Protein name: Fas-binding factor 1 (FBF-1) (Protein albatross)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBF1 in