DegronMD

Uniprot ID: Q8TES7

Source protein: Fas-binding factor 1

Source gene: FBF1

Class: DEG_SPOP_SBC_1

Location: 463:467

E3 ligase: SPOP

DEGRON score: 0.9688

ASA_SCORE: 81.18

COIL: 0.8358

CONS_SCORE: 0.4256

DSS_SCORE: 0.7866

HELIX: 0.1216

FCONS_SCORE: 1.0606

RIG_SCORE: 0.618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A474D	TCGA-AP-A059	UCEC	TCGA	PLTST	DEG_SPOP_SBC_1	0.1389
p.G468R	TCGA-DD-A1EC	LIHC	TCGA	PLTST	DEG_SPOP_SBC_1	0.3056
p.A473E	DO228952	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1667
p.P457H	DO229028	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1667
p.S459Y	DO229027	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.2222
p.T465N	DO229037	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.7055
p.G469R	DO22982	LIHC	ICGC	PLTST	DEG_SPOP_SBC_1	0.2778
p.P457S	DO229453	SKCA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1667
p.H456N	DO229216	THCA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1389
p.A475D	DO41361	UCEC	ICGC	PLTST	DEG_SPOP_SBC_1	0.1111
p.G469V	SIDM00087	Plasma Cell Myeloma	GDSC	PLTST	DEG_SPOP_SBC_1	0.2778
p.A473T	ACH-000816	Lung Cancer	CCLE	PLTST	DEG_SPOP_SBC_1	0.1667
p.A473T	NCI-H524	lung	COSMIC	PLTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons