DegronMD - Q5DID0(UMODL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D945H	TCGA-94-8491	LUSC	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.1944
p.D945H	DO219174	LUSC	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.1944
p.R936H	TCGA-A5-A2K5	UCEC	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8244
p.R936H	DO227906	COCA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8244
p.R936H	DO233898	GACA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8244
p.R936H	DO41379	UCEC	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8244
p.A938T	TCGA-AG-3892	READ	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7139
p.A938T	TCGA-E6-A1LX	UCEC	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7139
p.A938T	DO36394	READ	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7139
p.A938T	DO41020	UCEC	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7139
p.R936C	TCGA-AP-A056	UCEC	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	TCGA-CA-6718	COAD	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	TCGA-F5-6814	READ	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	DO7801	COAD	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	DO233231	GACA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	DO36556	READ	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.R936C	DO43971	UCEC	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8301
p.Y931D	TCGA-DK-A6AW	BLCA	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7325
p.Y931D	DO48566	BLCA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.7325
p.R944Q	TCGA-FR-A726	SKCM	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2222
p.R944Q	TCGA-UY-A8OC	BLCA	TCGA	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2222
p.R944Q	DO219038	BLCA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2222
p.R944Q	DO48665	SKCM	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2222
p.A700T	DO9876	COAD	ICGC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.1111
p.A700T	DO233830	GACA	ICGC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.1111
p.T669P	DO229013	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO229016	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO229003	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO229005	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO234285	ESAD	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO229346	LAML	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T669P	DO50984	LAML	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0833
p.T680M	DO229016	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7423
p.T680M	DO12634	GBM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7423
p.T680M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7423
p.V695F	DO228531	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.25
p.R930S	DO228948	LICA	ICGC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.3056
p.G683C	DO229019	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.6489
p.G683C	DO229034	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.6489
p.G683C	DO229009	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.6489
p.M698I	DO50935	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.1667
p.P676S	DO47569	SKCM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.2778
p.L694M	DO51251	SKCM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0556
p.L694M	DO51251	SKCM	ICGC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.2778
p.M668T	DO52402	UCEC	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.0556
p.R675Q	DO43971	UCEC	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.25
p.R675Q	ACH-000560	Gastric Cancer	CCLE	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.25
p.R675Q	ECC10	stomach	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.25
p.Q680H	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7582
p.S934P	SIDM01608	Endometrial Carcinoma	GDSC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.6752
p.E926Q	ACH-000173	Endometrial/Uterine Cancer	CCLE	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.1944
p.S679N	ACH-001369	Ovarian Cancer	CCLE	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7069
p.R939K	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.6126
p.D681H	SCC-9	upper aerodigestive tract	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7688
p.L942P	SNU-81	large intestine	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2778
p.S671L	SNU-1040	large intestine	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.1389
p.A679D	LS-411N	large intestine	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation altering degron motif	0.7793
p.G692R	MCC13	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation altering degron motif	0.7568
p.G692E	MCC13	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation altering degron motif	0.7199
p.M696T	IGR-37	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.2222
p.L935R	HCT-15	large intestine	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation altering degron motif	0.8428
p.I923F	OV-56	ovary	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.1111
p.L687P	L-540	haematopoietic and lymphoid tissue	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	678:684	Mutation rewiring degron network	0.25
p.L687P	L-540	haematopoietic and lymphoid tissue	COSMIC	PLTST	DEG_SPOP_SBC_1	688:692	Mutation rewiring degron network	0.3056
p.V928I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.25
p.A929T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DFPVEYSERP	CBL_PTK	931:940	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UMODL1

UniProt ID: Q5DID0

Entrez ID: 89766

Protein name: Uromodulin-like 1 (Olfactorin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UMODL1 in