DegronMD

Uniprot ID: Q5DID0

Source protein: Uromodulin-like 1

Source gene: UMODL1

Class: CBL_PTK

Location: 931:940

E3 ligase: CBL

DEGRON score: 0.9471

ASA_SCORE: 46.19

COIL: 0.805

CONS_SCORE: 0.7013

DSS_SCORE: 0.4401

HELIX: 0.102

FCONS_SCORE: 0.9486

RIG_SCORE: 0.7379

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D945H	TCGA-94-8491	LUSC	TCGA	DFPVEYSERP	CBL_PTK	0.1944
p.D945H	DO219174	LUSC	ICGC	DFPVEYSERP	CBL_PTK	0.1944
p.R936H	TCGA-A5-A2K5	UCEC	TCGA	DFPVEYSERP	CBL_PTK	0.8244
p.R936H	DO227906	COCA	ICGC	DFPVEYSERP	CBL_PTK	0.8244
p.R936H	DO233898	GACA	ICGC	DFPVEYSERP	CBL_PTK	0.8244
p.R936H	DO41379	UCEC	ICGC	DFPVEYSERP	CBL_PTK	0.8244
p.A938T	TCGA-AG-3892	READ	TCGA	DFPVEYSERP	CBL_PTK	0.7139
p.A938T	TCGA-E6-A1LX	UCEC	TCGA	DFPVEYSERP	CBL_PTK	0.7139
p.A938T	DO36394	READ	ICGC	DFPVEYSERP	CBL_PTK	0.7139
p.A938T	DO41020	UCEC	ICGC	DFPVEYSERP	CBL_PTK	0.7139
p.R936C	TCGA-AP-A056	UCEC	TCGA	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	TCGA-CA-6718	COAD	TCGA	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	TCGA-F5-6814	READ	TCGA	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	DO7801	COAD	ICGC	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	DO233231	GACA	ICGC	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	DO36556	READ	ICGC	DFPVEYSERP	CBL_PTK	0.8301
p.R936C	DO43971	UCEC	ICGC	DFPVEYSERP	CBL_PTK	0.8301
p.Y931D	TCGA-DK-A6AW	BLCA	TCGA	DFPVEYSERP	CBL_PTK	0.7325
p.Y931D	DO48566	BLCA	ICGC	DFPVEYSERP	CBL_PTK	0.7325
p.R944Q	TCGA-FR-A726	SKCM	TCGA	DFPVEYSERP	CBL_PTK	0.2222
p.R944Q	TCGA-UY-A8OC	BLCA	TCGA	DFPVEYSERP	CBL_PTK	0.2222
p.R944Q	DO219038	BLCA	ICGC	DFPVEYSERP	CBL_PTK	0.2222
p.R944Q	DO48665	SKCM	ICGC	DFPVEYSERP	CBL_PTK	0.2222
p.R930S	DO228948	LICA	ICGC	DFPVEYSERP	CBL_PTK	0.3056
p.S934P	SIDM01608	Endometrial Carcinoma	GDSC	DFPVEYSERP	CBL_PTK	0.6752
p.E926Q	ACH-000173	Endometrial/Uterine Cancer	CCLE	DFPVEYSERP	CBL_PTK	0.1944
p.R939K	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	DFPVEYSERP	CBL_PTK	0.6126
p.L942P	SNU-81	large_intestine	COSMIC	DFPVEYSERP	CBL_PTK	0.2778
p.L935R	HCT-15	large_intestine	COSMIC	DFPVEYSERP	CBL_PTK	0.8428
p.I923F	OV-56	ovary	COSMIC	DFPVEYSERP	CBL_PTK	0.1111
p.V928I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DFPVEYSERP	CBL_PTK	0.25
p.A929T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DFPVEYSERP	CBL_PTK	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DFPVEYSERP

Degron related mutations and impact score

Drug responses associated with UMODL1 mutations

All proteins holding degron of DFPVEYSERP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5DID0	Uromodulin-like 1	CBL_PTK	931:940	DFPVEYSERP	CBL	0.9471	More...