DegronMD

Uniprot ID: Q5DID0

Source protein: Uromodulin-like 1

Source gene: UMODL1

Class: DEG_SCF_TRCP1_1

Location: 678:684

E3 ligase: BTRC

DEGRON score: 0.9132

ASA_SCORE: 67.2143

COIL: 0.8411

CONS_SCORE: 0.6908

DSS_SCORE: 0.4481

HELIX: 0.0259

FCONS_SCORE: 0.9582

RIG_SCORE: 0.6202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T669P	DO229013	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO229016	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO229003	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO229005	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO234285	ESAD	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO229346	LAML	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T669P	DO50984	LAML	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0833
p.T680M	DO229016	COCA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.7423
p.T680M	DO12634	GBM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.7423
p.T680M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.7423
p.G683C	DO229019	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.6489
p.G683C	DO229034	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.6489
p.G683C	DO229009	LICA	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.6489
p.P676S	DO47569	SKCM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.2778
p.L694M	DO51251	SKCM	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0556
p.M668T	DO52402	UCEC	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.0556
p.R675Q	DO43971	UCEC	ICGC	DSGPSGS	DEG_SCF_TRCP1_1	0.25
p.R675Q	ACH-000560	Gastric Cancer	CCLE	DSGPSGS	DEG_SCF_TRCP1_1	0.25
p.R675Q	ECC10	stomach	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.25
p.Q680H	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	DSGPSGS	DEG_SCF_TRCP1_1	0.7582
p.S679N	ACH-001369	Ovarian Cancer	CCLE	DSGPSGS	DEG_SCF_TRCP1_1	0.7069
p.D681H	SCC-9	upper_aerodigestive_tract	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.7688
p.S671L	SNU-1040	large_intestine	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.1389
p.A679D	LS-411N	large_intestine	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.7793
p.L687P	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPSGS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5DID0	Uromodulin-like 1	DEG_SCF_TRCP1_1	678:684	DSGPSGS	BTRC	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPSGS

Degron related mutations and impact score

Drug responses associated with UMODL1 mutations

All proteins holding degron of DSGPSGS