DegronMD

Uniprot ID: Q5DID0

Source protein: Uromodulin-like 1

Source gene: UMODL1

Class: DEG_SPOP_SBC_1

Location: 688:692

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 80.4

COIL: 0.7656

CONS_SCORE: 0.7171

DSS_SCORE: 0.3629

HELIX: 0.0398

FCONS_SCORE: 1.0066

RIG_SCORE: 0.7876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A700T	DO9876	COAD	ICGC	PLTST	DEG_SPOP_SBC_1	0.1111
p.A700T	DO233830	GACA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1111
p.V695F	DO228531	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.25
p.M698I	DO50935	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1667
p.L694M	DO51251	SKCM	ICGC	PLTST	DEG_SPOP_SBC_1	0.2778
p.G692R	MCC13	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	0.7568
p.G692E	MCC13	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	0.7199
p.M696T	IGR-37	skin	COSMIC	PLTST	DEG_SPOP_SBC_1	0.2222
p.L687P	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PLTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons