DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SPOP_SBC_1

Location: 288:292

E3 ligase: SPOP

DEGRON score: 0.9317

ASA_SCORE: 98.5

COIL: 0.9574

CONS_SCORE: 0.4122

DSS_SCORE: 0.6043

HELIX: 0.0214

FCONS_SCORE: 0.9544

RIG_SCORE: 0.6635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T285R	DO224544	LUSC	ICGC	PLTST	DEG_SPOP_SBC_1	0.25
p.T285R	DO231014	LUSC	ICGC	PLTST	DEG_SPOP_SBC_1	0.25
p.P302S	DO222837	MELA	ICGC	PLTST	DEG_SPOP_SBC_1	0.0556
p.P288T	SIDM00255	Neuroblastoma	GDSC	PLTST	DEG_SPOP_SBC_1	0.7031
p.P288T	ACH-002282	Neuroblastoma	CCLE	PLTST	DEG_SPOP_SBC_1	0.7031
p.P288T	NB17	autonomic_ganglia	COSMIC	PLTST	DEG_SPOP_SBC_1	0.7031
p.S291T	ACH-001538	Bile Duct Cancer	CCLE	PLTST	DEG_SPOP_SBC_1	0.6005
p.A279V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PLTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons