DegronMD

Uniprot ID: Q9P2P1

Source protein: Protein NYNRIN

Source gene: NYNRIN

Class: DEG_SPOP_SBC_1

Location: 482:486

E3 ligase: SPOP

DEGRON score: 0.9851

ASA_SCORE: 66.14

COIL: 0.8772

CONS_SCORE: 0.4473

DSS_SCORE: 0.7372

HELIX: 0.0488

FCONS_SCORE: 1.4297

RIG_SCORE: 0.661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q478H	TCGA-AA-A010	COAD	TCGA	PLTST	DEG_SPOP_SBC_1	0.2222
p.G496V	TCGA-CR-7388	HNSC	TCGA	PLTST	DEG_SPOP_SBC_1	0.0556
p.G496V	DO14284	HNSC	ICGC	PLTST	DEG_SPOP_SBC_1	0.0556
p.P477S	TCGA-EE-A29M	SKCM	TCGA	PLTST	DEG_SPOP_SBC_1	0.1944
p.P477S	DO37404	SKCM	ICGC	PLTST	DEG_SPOP_SBC_1	0.1944
p.D475Y	DO229018	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1389
p.A491S	DO229034	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.1944
p.P495L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PLTST	DEG_SPOP_SBC_1	0.0833
p.P495L	NCI-H1975	lung	COSMIC	PLTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons