DegronMD

Uniprot ID: O15060

Source protein: Zinc finger and BTB domain-containing protein 39

Source gene: ZBTB39

Class: DEG_SPOP_SBC_1

Location: 133:137

E3 ligase: SPOP

DEGRON score: 0.9248

ASA_SCORE: 89.1

COIL: 0.8988

CONS_SCORE: 0.4836

DSS_SCORE: 0.6028

HELIX: 0.0562

FCONS_SCORE: 1.1635

RIG_SCORE: 0.6129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P123S	DO222363	MELA	ICGC	PLTST	DEG_SPOP_SBC_1	0.0556
p.S146N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLTST	DEG_SPOP_SBC_1	0.0833
p.S146N	ACH-000924	Lung Cancer	CCLE	PLTST	DEG_SPOP_SBC_1	0.0833
p.S146N	NCI-H2172	lung	COSMIC	PLTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons