DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.6619

ASA_SCORE: 85.1

COIL: 0.742

CONS_SCORE: 0.6214

DSS_SCORE: 0.6037

HELIX: 0.0182

FCONS_SCORE: 0.9463

RIG_SCORE: 0.6641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V346F	TCGA-50-5931	LUAD	TCGA	PLTST	DEG_SPOP_SBC_1	0.1389
p.V346F	DO24980	LUAD	ICGC	PLTST	DEG_SPOP_SBC_1	0.1389
p.A347V	TCGA-BK-A6W3	UCEC	TCGA	PLTST	DEG_SPOP_SBC_1	0.1111
p.A347V	DO50076	UCEC	ICGC	PLTST	DEG_SPOP_SBC_1	0.1111
p.T339M	DO882	BOCA	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.T339M	DO229016	COCA	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.T339M	DO230659	LAML	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.T339M	DO231140	LAML	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.T339M	DO228941	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.T339M	DO228947	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	0.7423
p.P345L	DO10858	ESAD	ICGC	PLTST	DEG_SPOP_SBC_1	0.1667
p.P325S	DO220907	MELA	ICGC	PLTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15060	Zinc finger and BTB domain-containing protein 39	DEG_SPOP_SBC_1	133:137	PLTST	SPOP	0.9248	More...
Q5DID0	Uromodulin-like 1	DEG_SPOP_SBC_1	688:692	PLTST	SPOP	0.9959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	335:339	PLTST	SPOP	0.6619	More...
Q8TES7	Fas-binding factor 1	DEG_SPOP_SBC_1	463:467	PLTST	SPOP	0.9688	More...
Q9P2P1	Protein NYNRIN	DEG_SPOP_SBC_1	482:486	PLTST	SPOP	0.9851	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	288:292	PLTST	SPOP	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons