DegronMD - Q9P2P1(NYNRIN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A662S	TCGA-06-5416	GBM	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1667
p.A662S	DO10880	GBM	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1667
p.Q478H	TCGA-AA-A010	COAD	TCGA	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.P987L	TCGA-AH-6903	READ	TCGA	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.2778
p.P987L	DO37299	READ	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.2778
p.E587K	TCGA-AP-A1DV	UCEC	TCGA	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	DO233261	GACA	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	DO222395	MELA	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	DO43186	UCEC	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	SIDM00193	Colorectal Carcinoma	GDSC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	ACH-000991	Colon/Colorectal Cancer	CCLE	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.E587K	SNU-81	large intestine	COSMIC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.G496V	TCGA-CR-7388	HNSC	TCGA	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0556
p.G496V	DO14284	HNSC	ICGC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0556
p.V971I	TCGA-DK-A1AC	BLCA	TCGA	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.1111
p.V971I	DO514	BLCA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.1111
p.P477S	TCGA-EE-A29M	SKCM	TCGA	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1944
p.P477S	DO37404	SKCM	ICGC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1944
p.R574Q	TCGA-EO-A22S	UCEC	TCGA	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation rewiring degron network	0.1111
p.R574Q	TCGA-EO-A22S	UCEC	TCGA	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.25
p.R574Q	TCGA-FW-A3R5	SKCM	TCGA	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation rewiring degron network	0.1111
p.R574Q	TCGA-FW-A3R5	SKCM	TCGA	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.25
p.R574Q	DO37406	SKCM	ICGC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation rewiring degron network	0.1111
p.R574Q	DO37406	SKCM	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.25
p.R574Q	DO41590	UCEC	ICGC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation rewiring degron network	0.1111
p.R574Q	DO41590	UCEC	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.25
p.K685T	TCGA-F5-6814	READ	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation substituting flanking lysine	0.1667
p.K685T	DO36556	READ	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation substituting flanking lysine	0.1667
p.S660F	TCGA-FW-A3R5	SKCM	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.S660F	DO37406	SKCM	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.A978T	DO229013	COCA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.3056
p.A978T	DO229505	LAML	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.3056
p.A978T	DO51023	LAML	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.3056
p.A978T	DO230993	LUSC	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.3056
p.P558S	DO228057	EOPC	ICGC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.5641
p.E582Q	DO50341	ESAD	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.6744
p.A662V	DO234336	ESAD	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1667
p.S660P	DO234336	ESAD	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.V579A	DO233272	GACA	ICGC	LAVHTE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.6936
p.S975I	DO228948	LICA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.2222
p.D475Y	DO229018	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1389
p.V668L	DO229019	LICA	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.5654
p.A491S	DO229034	LICA	ICGC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1944
p.E973D	DO229045	LICA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.1667
p.P558L	DO222843	MELA	ICGC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.6471
p.E990K	DO233544	PRAD	ICGC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.1944
p.V674I	SIDM01307	Colorectal Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.5965
p.N557T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.5944
p.P495L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0833
p.P495L	NCI-H1975	lung	COSMIC	PLTST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0833
p.S660A	SIDM00481	Ovarian Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.S660A	ACH-000116	Ovarian Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.S660A	OAW-28	ovary	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation blocking phosphorylation signal	0.5556
p.P678S	SIDM01186	Breast Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.25
p.P678S	ACH-000554	Breast Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.25
p.P678S	UACC-893	breast	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.25
p.N988S	SIDM00260	Gastric Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00989	Bladder Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00655	Other Solid Cancers	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00469	Pancreatic Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00169	Head and Neck Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00008	Ovarian Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.N988S	SIDM00248	Gastric Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation rewiring degron network	0.25
p.T680I	SIDM00444	Esophageal Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1944
p.T680I	ACH-001368	Esophageal Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1944
p.T680I	OACM5-1	oesophagus	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1944
p.A659V	SIDM00954	Breast Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0833
p.A659V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0833
p.A659V	SIDM01752	Pancreatic Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0833
p.A659V	SIDM01525	Acute Myeloid Leukemia	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0833
p.P666S	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.2778
p.P666S	SIDM01525	Acute Myeloid Leukemia	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.2778
p.V668A	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.V563M	SIDM00100	Mesothelioma	GDSC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.7208
p.V563M	ACH-002127	Lung Cancer	CCLE	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.7208
p.V563M	H2595	pleura	COSMIC	ENPSRTQVPSA	DEG_COP1_1	556:566	Mutation altering degron motif	0.7208
p.P982T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	979:985	Mutation altering degron motif	0.5919
p.A658T	ACH-000960	Leukemia	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NYNRIN

UniProt ID: Q9P2P1

Entrez ID: 57523

Protein name: Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Protein cousin of GIN1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NYNRIN in