DegronMD

Uniprot ID: Q9P2P1

Source protein: Protein NYNRIN

Source gene: NYNRIN

Class: DEG_SCF_FBW7_1

Location: 668:675

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 97.8

COIL: 0.961

CONS_SCORE: 0.2378

DSS_SCORE: 0.6261

HELIX: 0.013

FCONS_SCORE: 0.8689

RIG_SCORE: 0.6764

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A662S	TCGA-06-5416	GBM	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	0.1667
p.A662S	DO10880	GBM	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.1667
p.K685T	TCGA-F5-6814	READ	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	0.1667
p.K685T	DO36556	READ	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.1667
p.S660F	TCGA-FW-A3R5	SKCM	TCGA	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.S660F	DO37406	SKCM	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.A662V	DO234336	ESAD	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.1667
p.S660P	DO234336	ESAD	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.V668L	DO229019	LICA	ICGC	VPVTPRVS	DEG_SCF_FBW7_1	0.5654
p.V674I	SIDM01307	Colorectal Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.5965
p.S660A	SIDM00481	Ovarian Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.S660A	ACH-000116	Ovarian Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.S660A	OAW-28	ovary	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	0.5556
p.P678S	SIDM01186	Breast Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.25
p.P678S	ACH-000554	Breast Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	0.25
p.P678S	UACC-893	breast	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	0.25
p.T680I	SIDM00444	Esophageal Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.1944
p.T680I	ACH-001368	Esophageal Cancer	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	0.1944
p.T680I	OACM5-1	oesophagus	COSMIC	VPVTPRVS	DEG_SCF_FBW7_1	0.1944
p.A659V	SIDM00954	Breast Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.0833
p.A659V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.0833
p.A659V	SIDM01752	Pancreatic Carcinoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.0833
p.A659V	SIDM01525	Acute Myeloid Leukemia	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.0833
p.P666S	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.2778
p.P666S	SIDM01525	Acute Myeloid Leukemia	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.2778
p.V668A	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVTPRVS	DEG_SCF_FBW7_1	0.6936
p.A658T	ACH-000960	Leukemia	CCLE	VPVTPRVS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPVTPRVS

Degron related mutations and impact score

Drug responses associated with NYNRIN mutations

All proteins holding degron of VPVTPRVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P1	Protein NYNRIN	DEG_SCF_FBW7_1	668:675	VPVTPRVS	FBXW7	0.9939	More...