DegronMD

Uniprot ID: Q9P2P1

Source protein: Protein NYNRIN

Source gene: NYNRIN

Class: DEG_COP1_1

Location: 556:566

E3 ligase: COP1

DEGRON score: 0.9217

ASA_SCORE: 94.7091

COIL: 0.9197

CONS_SCORE: 0.4086

DSS_SCORE: 0.6354

HELIX: 0.0399

FCONS_SCORE: 0.8798

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R574Q	TCGA-EO-A22S	UCEC	TCGA	ENPSRTQVPSA	DEG_COP1_1	0.1111
p.R574Q	TCGA-FW-A3R5	SKCM	TCGA	ENPSRTQVPSA	DEG_COP1_1	0.1111
p.R574Q	DO37406	SKCM	ICGC	ENPSRTQVPSA	DEG_COP1_1	0.1111
p.R574Q	DO41590	UCEC	ICGC	ENPSRTQVPSA	DEG_COP1_1	0.1111
p.P558S	DO228057	EOPC	ICGC	ENPSRTQVPSA	DEG_COP1_1	0.5641
p.P558L	DO222843	MELA	ICGC	ENPSRTQVPSA	DEG_COP1_1	0.6471
p.N557T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ENPSRTQVPSA	DEG_COP1_1	0.5944
p.V563M	SIDM00100	Mesothelioma	GDSC	ENPSRTQVPSA	DEG_COP1_1	0.7208
p.V563M	ACH-002127	Lung Cancer	CCLE	ENPSRTQVPSA	DEG_COP1_1	0.7208
p.V563M	H2595	pleura	COSMIC	ENPSRTQVPSA	DEG_COP1_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P1	Protein NYNRIN	DEG_COP1_1	556:566	ENPSRTQVPSA	COP1	0.9217	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons