DegronMD

Uniprot ID: Q9P2P1

Source protein: Protein NYNRIN

Source gene: NYNRIN

Class: DEG_SCF_TRCP1_1

Location: 979:985

E3 ligase: BTRC

DEGRON score: 0.8296

ASA_SCORE: 59.2143

COIL: 0.715

CONS_SCORE: 0.3944

DSS_SCORE: 0.7329

HELIX: 0.1886

FCONS_SCORE: 1.0474

RIG_SCORE: 0.6013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P987L	TCGA-AH-6903	READ	TCGA	DSGPLES	DEG_SCF_TRCP1_1	0.2778
p.P987L	DO37299	READ	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.2778
p.V971I	TCGA-DK-A1AC	BLCA	TCGA	DSGPLES	DEG_SCF_TRCP1_1	0.1111
p.V971I	DO514	BLCA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.1111
p.A978T	DO229013	COCA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.3056
p.A978T	DO229505	LAML	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.3056
p.A978T	DO51023	LAML	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.3056
p.A978T	DO230993	LUSC	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.3056
p.S975I	DO228948	LICA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.2222
p.E973D	DO229045	LICA	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.1667
p.E990K	DO233544	PRAD	ICGC	DSGPLES	DEG_SCF_TRCP1_1	0.1944
p.N988S	SIDM00260	Gastric Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00989	Bladder Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00655	Other Solid Cancers	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00469	Pancreatic Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00169	Head and Neck Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00008	Ovarian Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.N988S	SIDM00248	Gastric Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.25
p.P982T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	DSGPLES	DEG_SCF_TRCP1_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P1	Protein NYNRIN	DEG_SCF_TRCP1_1	979:985	DSGPLES	BTRC	0.8296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons