DegronMD

Uniprot ID: Q9P2P1

Source protein: Protein NYNRIN

Source gene: NYNRIN

Class: LIG_APCC_ABBA_1

Location: 577:582

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5702

ASA_SCORE: 90.2333

COIL: 0.6943

CONS_SCORE: 0.4812

DSS_SCORE: 0.5365

HELIX: 0.2258

FCONS_SCORE: 1.2332

RIG_SCORE: 0.7091

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V579A	DO233272	GACA	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.6936
p.E582Q	DO50341	ESAD	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.6744
p.R574Q	TCGA-EO-A22S	UCEC	TCGA	LAVHTE	LIG_APCC_ABBA_1	0.25
p.R574Q	TCGA-FW-A3R5	SKCM	TCGA	LAVHTE	LIG_APCC_ABBA_1	0.25
p.R574Q	DO37406	SKCM	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.25
p.R574Q	DO41590	UCEC	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.25
p.E587K	TCGA-AP-A1DV	UCEC	TCGA	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	DO233261	GACA	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	DO222395	MELA	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	DO43186	UCEC	ICGC	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	SIDM00193	Colorectal Carcinoma	GDSC	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	ACH-000991	Colon/Colorectal Cancer	CCLE	LAVHTE	LIG_APCC_ABBA_1	0.1944
p.E587K	SNU-81	large_intestine	COSMIC	LAVHTE	LIG_APCC_ABBA_1	0.1944

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P1	Protein NYNRIN	LIG_APCC_ABBA_1	577:582	LAVHTE	APC,CDC20,FZR1	0.5702	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons