DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAVHTE
Uniprot ID:
Q9P2P1
Source protein:
Protein NYNRIN
Source gene:
NYNRIN
Class:
LIG_APCC_ABBA_1
Location:
577:582
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5702
ASA_SCORE:
90.2333
COIL:
0.6943
CONS_SCORE:
0.4812
DSS_SCORE:
0.5365
HELIX:
0.2258
FCONS_SCORE:
1.2332
RIG_SCORE:
0.7091
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E587K
TCGA-AP-A1DV
UCEC
TCGA
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
DO233261
GACA
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
DO222395
MELA
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
DO43186
UCEC
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
SIDM00193
Colorectal Carcinoma
GDSC
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
ACH-000991
Colon/Colorectal Cancer
CCLE
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.E587K
SNU-81
large_intestine
COSMIC
LAVHTE
LIG_APCC_ABBA_1
0.1944
p.R574Q
TCGA-EO-A22S
UCEC
TCGA
LAVHTE
LIG_APCC_ABBA_1
0.25
p.R574Q
TCGA-FW-A3R5
SKCM
TCGA
LAVHTE
LIG_APCC_ABBA_1
0.25
p.R574Q
DO37406
SKCM
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.25
p.R574Q
DO41590
UCEC
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.25
p.E582Q
DO50341
ESAD
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.6744
p.V579A
DO233272
GACA
ICGC
LAVHTE
LIG_APCC_ABBA_1
0.6936
Drug responses associated with NYNRIN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAVHTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2P1
Protein NYNRIN
LIG_APCC_ABBA_1
577:582
LAVHTE
APC,CDC20,FZR1
0.5702
More...