DegronMD

Uniprot ID: Q8TES7

Source protein: Fas-binding factor 1

Source gene: FBF1

Class: DEG_SCF_FBW7_1

Location: 188:195

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 84.2625

COIL: 0.9523

CONS_SCORE: 0.4335

DSS_SCORE: 0.7027

HELIX: 0.0212

FCONS_SCORE: 1.1474

RIG_SCORE: 0.6513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E202K	TCGA-AF-2687	READ	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	0.1389
p.E202K	DO36902	READ	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.1389
p.R198Q	TCGA-AP-A056	UCEC	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	0.25
p.R198Q	DO234183	ESAD	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.25
p.R198Q	DO43971	UCEC	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.25
p.R198Q	SiHa	cervix	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.25
p.P178H	TCGA-ER-A1A1	SKCM	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.P178H	TCGA-G2-A2EJ	BLCA	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.P178H	DO554	BLCA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.P178H	DO37413	SKCM	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.G193V	TCGA-SJ-A6ZI	UCEC	TCGA	IPLTPGDT	DEG_SCF_FBW7_1	0.6421
p.G193V	DO219784	UCEC	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.6421
p.T180K	DO228952	LICA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.5556
p.P189T	DO229035	LICA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.5919
p.S187P	DO229211	THCA	ICGC	IPLTPGDT	DEG_SCF_FBW7_1	0.3056
p.P179S	SIDM00107	Melanoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.P179S	UACC-62	skin	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.P179L	SIDM00014	Colorectal Carcinoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.P179L	SIDM00683	Prostate Carcinoma	GDSC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.P179L	LIM1215	large_intestine	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.P179L	LNCaP-Clone-FGC	prostate	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0833
p.Q184P	ACH-000484	Kidney Cancer	CCLE	IPLTPGDT	DEG_SCF_FBW7_1	0.2222
p.L203S	ACH-000981	Leukemia	CCLE	IPLTPGDT	DEG_SCF_FBW7_1	0.1111
p.P178L	LNCaP-Clone-FGC	prostate	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.P178L	LIM1215	large_intestine	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0556
p.P178S	UACC-62	skin	COSMIC	IPLTPGDT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TES7	Fas-binding factor 1	DEG_SCF_FBW7_1	188:195	IPLTPGDT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPLTPGDT

Degron related mutations and impact score

Drug responses associated with FBF1 mutations

All proteins holding degron of IPLTPGDT