DegronMD

Uniprot ID: P33993

Source protein: DNA replication licensing factor MCM7

Source gene: MCM7

Class: DEG_APCC_DBOX_1

Location: 603:611

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7244

ASA_SCORE: 27.8667

COIL: 0.0176

CONS_SCORE: 0.8312

DSS_SCORE: 0.0531

HELIX: 0.9788

FCONS_SCORE: 1.2752

RIG_SCORE: 0.9325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R620G	DO234213	ESAD	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	0.0833
p.R611S	DO229015	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	0.6316
p.R618S	DO229028	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	0.1389
p.L607M	DO229041	LICA	ICGC	ARTLLAILR	DEG_APCC_DBOX_1	0.711
p.S595N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	0.1111
p.S595N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	0.1111
p.R611C	SIDM00217	Colorectal Carcinoma	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	0.719
p.R611C	ACH-000999	Colon/Colorectal Cancer	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	0.719
p.R611C	SNU-1040	large_intestine	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	0.719
p.R611H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARTLLAILR	DEG_APCC_DBOX_1	0.7133
p.R611H	ACH-001127	Leukemia	CCLE	ARTLLAILR	DEG_APCC_DBOX_1	0.7133
p.R611H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARTLLAILR	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33993	DNA replication licensing factor MCM7	DEG_APCC_DBOX_1	603:611	ARTLLAILR	APC,CDC20,FZR1	0.7244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons