DegronMD

Uniprot ID: Q9P0L2

Source protein: Serine/threonine-protein kinase MARK1

Source gene: MARK1

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 99.7222

COIL: 0.9616

CONS_SCORE: 0.2892

DSS_SCORE: 0.8484

HELIX: 0.0251

FCONS_SCORE: 1.1167

RIG_SCORE: 0.6686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3S	TCGA-DC-5869	READ	TCGA	ARTPLPTVN	DEG_APCC_DBOX_1	0.6477
p.A3S	DO36584	READ	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	0.6477
p.S20C	TCGA-GI-A2C8	BRCA	TCGA	ARTPLPTVN	DEG_APCC_DBOX_1	0.0833
p.S20C	DO5992	BRCA	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	0.0833
p.A4T	DO50090	COAD	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	0.7139
p.P8S	DO45299	LIRI	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	0.5641
p.S20F	DO230524	LUSC	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0L2	Serine/threonine-protein kinase MARK1	DEG_APCC_DBOX_1	3:11	ARTPLPTVN	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons