DegronMD - Q9P0L2(MARK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H315Y	TCGA-17-Z010	LUAD	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1944
p.E317Q	TCGA-C5-A1M6	CESC	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.25
p.D329N	TCGA-C8-A12P	BRCA	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.D329N	TCGA-S3-A6ZF	BRCA	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.M311L	TCGA-CV-6952	HNSC	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0833
p.A3S	TCGA-DC-5869	READ	TCGA	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6477
p.A3S	DO36584	READ	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6477
p.P328L	TCGA-DX-A8BL	SARC	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.25
p.E318A	TCGA-EE-A2MF	SKCM	TCGA	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2778
p.S20C	TCGA-GI-A2C8	BRCA	TCGA	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.S20C	DO5992	BRCA	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.D325H	DO218984	BLCA	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.7688
p.A4T	DO50090	COAD	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7139
p.R324Q	DO8842	COAD	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.7329
p.R324Q	DO37547	SKCM	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.7329
p.R324Q	DO41133	UCEC	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.7329
p.Q334K	DO228581	GACA	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation substituting flanking lysine	0.1944
p.I332V	DO15166	HNSC	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.R313I	DO229031	LICA	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.P8S	DO45299	LIRI	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.5641
p.M317I	DO23564	LUAD	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.25
p.S20F	DO230524	LUSC	ICGC	ARTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.D325N	DO47401	SKCM	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.6932
p.D329E	DO229275	THCA	ICGC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.M311V	SIDM01045	Endometrial Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0833
p.M311V	ACH-000978	Endometrial/Uterine Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0833
p.M311V	EN	endometrium	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0833
p.E316K	SIDM00217	Colorectal Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.E316K	ACH-000999	Colon/Colorectal Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.E316K	SNU-1040	large intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.N331S	SIDM01033	Bladder Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1667
p.N331S	ACH-000486	Bladder Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1667
p.N331S	KU-19-19	urinary tract	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1667
p.Y323H	SIDM01318	Hepatocellular Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.6118
p.Y323H	ACH-001318	Liver Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.6118
p.R335I	SIDM01611	Endometrial Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0556
p.R335I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.0556
p.I316M	TK10	kidney	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2222
p.T319A	SNU-1040	large intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.3056
p.A323T	HCT-15	large intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.7139

Kaplan plot for MARK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MARK1

UniProt ID: Q9P0L2

Entrez ID: 4139

Protein name: Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MARK1 in