DegronMD

Uniprot ID: Q9P0L2

Source protein: Serine/threonine-protein kinase MARK1

Source gene: MARK1

Class: LIG_APCC_ABBA_1

Location: 320:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8267

ASA_SCORE: 89.9833

COIL: 0.911

CONS_SCORE: 0.3649

DSS_SCORE: 0.5889

HELIX: 0.0387

FCONS_SCORE: 0.8723

RIG_SCORE: 0.7076

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H315Y	TCGA-17-Z010	LUAD	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.1944
p.E317Q	TCGA-C5-A1M6	CESC	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.25
p.D329N	TCGA-C8-A12P	BRCA	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.D329N	TCGA-S3-A6ZF	BRCA	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.M311L	TCGA-CV-6952	HNSC	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.0833
p.P328L	TCGA-DX-A8BL	SARC	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.25
p.E318A	TCGA-EE-A2MF	SKCM	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.2778
p.D325H	DO218984	BLCA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.7688
p.R324Q	DO8842	COAD	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.7329
p.R324Q	DO37547	SKCM	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.7329
p.R324Q	DO41133	UCEC	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.7329
p.Q334K	DO228581	GACA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.1944
p.I332V	DO15166	HNSC	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.R313I	DO229031	LICA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.M317I	DO23564	LUAD	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.25
p.D325N	DO47401	SKCM	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.6932
p.D329E	DO229275	THCA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.M311V	SIDM01045	Endometrial Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.0833
p.M311V	ACH-000978	Endometrial/Uterine Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.0833
p.M311V	EN	endometrium	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.0833
p.E316K	SIDM00217	Colorectal Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.E316K	ACH-000999	Colon/Colorectal Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.E316K	SNU-1040	large_intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.N331S	SIDM01033	Bladder Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1667
p.N331S	ACH-000486	Bladder Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1667
p.N331S	KU-19-19	urinary_tract	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.1667
p.Y323H	SIDM01318	Hepatocellular Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.6118
p.Y323H	ACH-001318	Liver Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.6118
p.R335I	SIDM01611	Endometrial Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.0556
p.R335I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.0556
p.I316M	TK10	kidney	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.T319A	SNU-1040	large_intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.3056
p.A323T	HCT-15	large_intestine	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L34	MAP/microtubule affinity-regulating kinase 4	LIG_APCC_ABBA_1	319:324	LKPYTE	APC,CDC20,FZR1	0.8628	More...
Q9P0L2	Serine/threonine-protein kinase MARK1	LIG_APCC_ABBA_1	320:325	LKPYTE	APC,CDC20,FZR1	0.8267	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKPYTE

Degron related mutations and impact score

Drug responses associated with MARK1 mutations

All proteins holding degron of LKPYTE