DegronMD

Uniprot ID: Q96L34

Source protein: MAP/microtubule affinity-regulating kinase 4

Source gene: MARK4

Class: LIG_APCC_ABBA_1

Location: 319:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8628

ASA_SCORE: 84.6

COIL: 0.934

CONS_SCORE: 0.3841

DSS_SCORE: 0.4622

HELIX: 0.0165

FCONS_SCORE: 0.9378

RIG_SCORE: 0.7532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G316C	TCGA-AP-A059	UCEC	TCGA	LKPYTE	LIG_APCC_ABBA_1	0.25
p.G316C	DO229029	LICA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.25
p.G316C	DO41361	UCEC	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.25
p.G330R	DO233654	GACA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.1667
p.D331Y	DO228952	LICA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.EE326DK	DO222632	MELA	ICGC	LKPYTE	LIG_APCC_ABBA_1	0
p.I312V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	SIDM00489	Oral Cavity Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	SIDM01257	Hepatocellular Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	SIDM01569	Hepatocellular Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	SIDM01412	Oral Cavity Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	SIDM00062	Hepatocellular Carcinoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-000442	Lung Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-000671	Liver Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-000734	Liver Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-000762	Head and Neck Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-002043	Head and Neck Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	ACH-002395	Liver Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	HUH-6-clone5	liver	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	RERF-LC-Sq1	lung	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.I312V	Ca9-22	upper_aerodigestive_tract	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.1389
p.D328N	SIDM01228	Melanoma	GDSC	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.D328N	ACH-000931	Skin Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.D328N	ACH-001024	Skin Cancer	CCLE	LKPYTE	LIG_APCC_ABBA_1	0.2222
p.D328N	CHL-1	skin	COSMIC	LKPYTE	LIG_APCC_ABBA_1	0.2222

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00309	MESO\|mesothelioma	p.G252S (No)	GDSC	XMD11-85h	28.7964
SIDM01086	ALL\|leukemia	p.G427R (No)	GDSC	XMD11-85h	10.2477
SIDM01045	UCEC\|endometrium	p.G681fs*100 (No)	GDSC	XMD11-85h	219.324
SIDM00499	PRAD\|prostate	p.R265Q (No)	GDSC	XMD11-85h	23.6009
SIDM00732	GBM\|glioma	p.S149L (No)	GDSC	XMD11-85h	32.9121
SIDM00354	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.I312V (Yes)	GDSC	XMD11-85h	33.833
SIDM00498	COREAD\|large_intestine	p.T145P (No)	GDSC	XMD11-85h	80.644
SIDM00498	COREAD\|large_intestine	p.A684T (No)	GDSC	XMD11-85h	80.644
SIDM00999	BLCA\|bladder	p.R490Q (No)	GDSC	XMD11-85h	23.1162
SIDM00681	COREAD\|large_intestine	p.R418C (No)	GDSC	XMD11-85h	71.4632
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R678C (No)	GDSC	XMD11-85h	10.6278
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.S406G (No)	GDSC	XMD11-85h	215.635
SIDM00596	UCEC\|endometrium	p.R418C (No)	GDSC	XMD11-85h	51.6611
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.A457V (No)	GDSC	XMD11-85h	95.5497
SIDM00150	COREAD\|large_intestine	p.R36H (No)	GDSC	XMD11-85h	148.5934
SIDM01179	UNCLASSIFIED\|soft_tissue_other	p.T145P (No)	GDSC	XMD11-85h	117.5333
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P276S (No)	GDSC	XMD11-85h	238.7132
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S406G (No)	GDSC	XMD11-85h	23.7363
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.E142K (No)	GDSC	XMD11-85h	32.5195
SIDM00817	KIRC\|kidney	p.Y416H (No)	GDSC	XMD11-85h	50.4368
SIDM00193	COREAD\|large_intestine	p.S406N (No)	GDSC	XMD11-85h	111.2169
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R386L (No)	GDSC	XMD11-85h	178.2518

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L34	MAP/microtubule affinity-regulating kinase 4	LIG_APCC_ABBA_1	319:324	LKPYTE	APC,CDC20,FZR1	0.8628	More...
Q9P0L2	Serine/threonine-protein kinase MARK1	LIG_APCC_ABBA_1	320:325	LKPYTE	APC,CDC20,FZR1	0.8267	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKPYTE

Degron related mutations and impact score

Drug responses associated with MARK4 mutations

All proteins holding degron of LKPYTE