DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARVPLLHLR
Uniprot ID:
A7KAX9
Source protein:
Rho GTPase-activating protein 32
Source gene:
ARHGAP32
Class:
DEG_APCC_DBOX_1
Location:
1390:1398
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9649
ASA_SCORE:
100.8
COIL:
0.8438
CONS_SCORE:
0.3347
DSS_SCORE:
0.4226
HELIX:
0.1351
FCONS_SCORE:
0.9945
RIG_SCORE:
0.7407
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1387L
TCGA-28-5211
GBM
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.25
p.R1398L
TCGA-78-8662
LUAD
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.7316
p.R1391Q
TCGA-A4-8098
KIRP
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.7329
p.P1403S
TCGA-B5-A11E
UCEC
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.1944
p.A1404V
TCGA-B5-A1MX
UCEC
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.1667
p.R1398C
TCGA-BR-4292
STAD
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.719
p.R1398C
SIDM00498
Colorectal Carcinoma
GDSC
ARVPLLHLR
DEG_APCC_DBOX_1
0.719
p.R1398C
SNU-C5
large_intestine
COSMIC
ARVPLLHLR
DEG_APCC_DBOX_1
0.719
p.L1395P
TCGA-CM-6674
COAD
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.6471
p.A1390T
TCGA-NI-A8LF
LIHC
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.6028
p.P1406L
TCGA-W3-A825
SKCM
TCGA
ARVPLLHLR
DEG_APCC_DBOX_1
0.1111
p.D1385N
DO219049
BLCA
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.3056
p.S1392L
DO1088
BRCA
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.7667
p.R1402C
DO230335
COCA
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.2222
p.Y1401F
DO234171
ESAD
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.6944
p.M1398I
DO23624
LUAD
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.7618
p.P1382S
DO41752
UCEC
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.1111
p.R1407W
DO43755
UCEC
ICGC
ARVPLLHLR
DEG_APCC_DBOX_1
0.0833
p.E1400K
SIDM00731
Small Cell Lung Carcinoma
GDSC
ARVPLLHLR
DEG_APCC_DBOX_1
0.2778
p.E1400K
NCI-H2196
lung
COSMIC
ARVPLLHLR
DEG_APCC_DBOX_1
0.2778
p.G1389S
SIDM00404
B-Cell Non-Hodgkin's Lymphoma
GDSC
ARVPLLHLR
DEG_APCC_DBOX_1
0.3056
p.G1389S
SU-DHL-16
haematopoietic_and_lymphoid_tissue
COSMIC
ARVPLLHLR
DEG_APCC_DBOX_1
0.3056
p.H1396Y
SIDM01617
Endometrial Carcinoma
GDSC
ARVPLLHLR
DEG_APCC_DBOX_1
0.6118
p.A1383P
ACH-001451
Cervical Cancer
CCLE
ARVPLLHLR
DEG_APCC_DBOX_1
0.1389
p.P1382L
SUP-M2
haematopoietic_and_lymphoid_tissue
COSMIC
ARVPLLHLR
DEG_APCC_DBOX_1
0.1111
Drug responses associated with ARHGAP32 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARVPLLHLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A7KAX9
Rho GTPase-activating protein 32
DEG_APCC_DBOX_1
1390:1398
ARVPLLHLR
APC,CDC20,FZR1
0.9649
More...