DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
CIR
Uniprot ID:
Q5TYM5
Source protein:
Protein FAM72A
Source gene:
FAM72A
Class:
DEG_APCC_TPR_1
Location:
147:149
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5941
ASA_SCORE:
87.9
COIL:
0.4197
CONS_SCORE:
0.7699
DSS_SCORE:
0.707
HELIX:
0.5593
FCONS_SCORE:
1.2379
RIG_SCORE:
0.8388
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R149K
TCGA-WB-A81P
PCPG
TCGA
CIR
DEG_APCC_TPR_1
0.7237
p.D138N
SIDM00375
Head and Neck Carcinoma
GDSC
CIR
DEG_APCC_TPR_1
0.0833
Drug responses associated with FAM72A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of CIR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TYM5
Protein FAM72A
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.5941
More...
Q86X60
Protein FAM72B
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.7107
More...