DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
CIR
Uniprot ID:
Q86X60
Source protein:
Protein FAM72B
Source gene:
FAM72B
Class:
DEG_APCC_TPR_1
Location:
147:149
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7107
ASA_SCORE:
87.7333
COIL:
0.4197
CONS_SCORE:
0.7751
DSS_SCORE:
0.7036
HELIX:
0.562
FCONS_SCORE:
1.2753
RIG_SCORE:
0.8388
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R149I
TCGA-AX-A1CE
UCEC
TCGA
CIR
DEG_APCC_TPR_1
0.8102
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Drug responses associated with FAM72B mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of CIR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TYM5
Protein FAM72A
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.5941
More...
Q86X60
Protein FAM72B
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.7107
More...
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