DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
CIR
Uniprot ID:
Q86X60
Source protein:
Protein FAM72B
Source gene:
FAM72B
Class:
DEG_APCC_TPR_1
Location:
147:149
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7107
ASA_SCORE:
87.7333
COIL:
0.4197
CONS_SCORE:
0.7751
DSS_SCORE:
0.7036
HELIX:
0.562
FCONS_SCORE:
1.2753
RIG_SCORE:
0.8388
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R149I
TCGA-AX-A1CE
UCEC
TCGA
CIR
DEG_APCC_TPR_1
0.8102
Drug responses associated with FAM72B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of CIR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TYM5
Protein FAM72A
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.5941
More...
Q86X60
Protein FAM72B
DEG_APCC_TPR_1
147:149
CIR
APC,CDC20,FZR1
0.7107
More...