DegronMD

Uniprot ID: Q9HCE1

Source protein: Helicase MOV-10

Source gene: MOV10

Class: DEG_APCC_KENBOX_2

Location: 938:942

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6692

ASA_SCORE: 65.98

COIL: 0.3758

CONS_SCORE: 0.5572

DSS_SCORE: 0.0868

HELIX: 0.6224

FCONS_SCORE: 1.2484

RIG_SCORE: 0.796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E940Q	TCGA-30-1718	OV	TCGA	CKENG	DEG_APCC_KENBOX_2	0.6744
p.E940Q	DO32708	OV	ICGC	CKENG	DEG_APCC_KENBOX_2	0.6744
p.E936Q	TCGA-AC-A5XS	BRCA	TCGA	CKENG	DEG_APCC_KENBOX_2	0.2778
p.E936Q	DO50023	BRCA	ICGC	CKENG	DEG_APCC_KENBOX_2	0.2778
p.L935M	TCGA-FS-A1ZN	SKCM	TCGA	CKENG	DEG_APCC_KENBOX_2	0.25
p.L935M	DO38165	SKCM	ICGC	CKENG	DEG_APCC_KENBOX_2	0.25
p.D928G	DO230346	COCA	ICGC	CKENG	DEG_APCC_KENBOX_2	0.0556
p.K952T	DO49427	PACA	ICGC	CKENG	DEG_APCC_KENBOX_2	0.5
p.N941K	SIDM01588	Endometrial Carcinoma	GDSC	CKENG	DEG_APCC_KENBOX_2	0.6918
p.N941K	ACH-000993	Endometrial/Uterine Cancer	CCLE	CKENG	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE1	Helicase MOV-10	DEG_APCC_KENBOX_2	938:942	CKENG	APC,CDC20,FZR1	0.6692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons