DegronMD - Q9HCE1(MOV10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E940Q	TCGA-30-1718	OV	TCGA	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6744
p.E940Q	DO32708	OV	ICGC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6744
p.E936Q	TCGA-AC-A5XS	BRCA	TCGA	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.2778
p.E936Q	TCGA-AC-A5XS	BRCA	TCGA	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.1944
p.E936Q	DO50023	BRCA	ICGC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.2778
p.E936Q	DO50023	BRCA	ICGC	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.1944
p.P948L	TCGA-BH-A0HF	BRCA	TCGA	NGGYTGCP	CBL_PTK	941:948	Mutation altering degron motif	0.7582
p.P948L	DO1749	BRCA	ICGC	NGGYTGCP	CBL_PTK	941:948	Mutation altering degron motif	0.7582
p.L935M	TCGA-FS-A1ZN	SKCM	TCGA	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.25
p.L935M	TCGA-FS-A1ZN	SKCM	TCGA	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.1667
p.L935M	DO38165	SKCM	ICGC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.25
p.L935M	DO38165	SKCM	ICGC	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.1667
p.D928G	DO230346	COCA	ICGC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.0556
p.K952T	DO49427	PACA	ICGC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation blocking ubiquitination signal	0.5
p.K952T	DO49427	PACA	ICGC	NGGYTGCP	CBL_PTK	941:948	Mutation blocking ubiquitination signal	0.6667
p.Q957R	SIDM01612	Endometrial Carcinoma	GDSC	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.0833
p.Q957R	ACH-000946	Endometrial/Uterine Cancer	CCLE	NGGYTGCP	CBL_PTK	941:948	Mutation rewiring degron network	0.0833
p.N941K	SIDM01588	Endometrial Carcinoma	GDSC	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6918
p.N941K	SIDM01588	Endometrial Carcinoma	GDSC	NGGYTGCP	CBL_PTK	941:948	Mutation altering degron motif	0.6918
p.N941K	ACH-000993	Endometrial/Uterine Cancer	CCLE	CKENG	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6918
p.N941K	ACH-000993	Endometrial/Uterine Cancer	CCLE	NGGYTGCP	CBL_PTK	941:948	Mutation altering degron motif	0.6918

Kaplan plot for MOV10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MOV10

UniProt ID: Q9HCE1

Entrez ID: 4343

Protein name: Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MOV10 in