DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NGGYTGCP
Uniprot ID:
Q9HCE1
Source protein:
Helicase MOV-10
Source gene:
MOV10
Class:
CBL_PTK
Location:
941:948
E3 ligase:
CBL
DEGRON score:
0.7402
ASA_SCORE:
38.1
COIL:
0.7273
CONS_SCORE:
0.5341
DSS_SCORE:
0.1492
HELIX:
0.038
FCONS_SCORE:
1.3878
RIG_SCORE:
0.7457
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E936Q
TCGA-AC-A5XS
BRCA
TCGA
NGGYTGCP
CBL_PTK
0.1944
p.E936Q
DO50023
BRCA
ICGC
NGGYTGCP
CBL_PTK
0.1944
p.P948L
TCGA-BH-A0HF
BRCA
TCGA
NGGYTGCP
CBL_PTK
0.7582
p.P948L
DO1749
BRCA
ICGC
NGGYTGCP
CBL_PTK
0.7582
p.L935M
TCGA-FS-A1ZN
SKCM
TCGA
NGGYTGCP
CBL_PTK
0.1667
p.L935M
DO38165
SKCM
ICGC
NGGYTGCP
CBL_PTK
0.1667
p.K952T
DO49427
PACA
ICGC
NGGYTGCP
CBL_PTK
0.6667
p.Q957R
SIDM01612
Endometrial Carcinoma
GDSC
NGGYTGCP
CBL_PTK
0.0833
p.Q957R
ACH-000946
Endometrial/Uterine Cancer
CCLE
NGGYTGCP
CBL_PTK
0.0833
p.N941K
SIDM01588
Endometrial Carcinoma
GDSC
NGGYTGCP
CBL_PTK
0.6918
p.N941K
ACH-000993
Endometrial/Uterine Cancer
CCLE
NGGYTGCP
CBL_PTK
0.6918
Drug responses associated with MOV10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGGYTGCP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCE1
Helicase MOV-10
CBL_PTK
941:948
NGGYTGCP
CBL
0.7402
More...
