DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NGGYTGCP
Uniprot ID:
Q9HCE1
Source protein:
Helicase MOV-10
Source gene:
MOV10
Class:
CBL_PTK
Location:
941:948
E3 ligase:
CBL
DEGRON score:
0.7402
ASA_SCORE:
38.1
COIL:
0.7273
CONS_SCORE:
0.5341
DSS_SCORE:
0.1492
HELIX:
0.038
FCONS_SCORE:
1.3878
RIG_SCORE:
0.7457
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P948L
TCGA-BH-A0HF
BRCA
TCGA
NGGYTGCP
CBL_PTK
0.7582
p.P948L
DO1749
BRCA
ICGC
NGGYTGCP
CBL_PTK
0.7582
p.N941K
SIDM01588
Endometrial Carcinoma
GDSC
NGGYTGCP
CBL_PTK
0.6918
p.N941K
ACH-000993
Endometrial/Uterine Cancer
CCLE
NGGYTGCP
CBL_PTK
0.6918
p.K952T
DO49427
PACA
ICGC
NGGYTGCP
CBL_PTK
0.6667
p.E936Q
TCGA-AC-A5XS
BRCA
TCGA
NGGYTGCP
CBL_PTK
0.1944
p.E936Q
DO50023
BRCA
ICGC
NGGYTGCP
CBL_PTK
0.1944
p.L935M
TCGA-FS-A1ZN
SKCM
TCGA
NGGYTGCP
CBL_PTK
0.1667
p.L935M
DO38165
SKCM
ICGC
NGGYTGCP
CBL_PTK
0.1667
p.Q957R
SIDM01612
Endometrial Carcinoma
GDSC
NGGYTGCP
CBL_PTK
0.0833
p.Q957R
ACH-000946
Endometrial/Uterine Cancer
CCLE
NGGYTGCP
CBL_PTK
0.0833
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Drug responses associated with MOV10 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of NGGYTGCP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCE1
Helicase MOV-10
CBL_PTK
941:948
NGGYTGCP
CBL
0.7402
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