DegronMD

Uniprot ID: O15304

Source protein: Apoptosis regulatory protein Siva

Source gene: SIVA1

Class: DEG_SIAH_1

Location: 6:14

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.647

ASA_SCORE: 59.8556

COIL: 0.779

CONS_SCORE: 0.6049

DSS_SCORE: 0.3262

HELIX: 0.1924

FCONS_SCORE: 0.7781

RIG_SCORE: 0.7995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q15H	DO229038	LICA	ICGC	CPFADVAPL	DEG_SIAH_1	0.3056
p.R4W	DO230961	LUSC	ICGC	CPFADVAPL	DEG_SIAH_1	0.2778
p.R4W	DO224594	LUSC	ICGC	CPFADVAPL	DEG_SIAH_1	0.2778
p.P7R	SIDM02037	Pancreatic Carcinoma	GDSC	CPFADVAPL	DEG_SIAH_1	0.7512
p.A12T	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	CPFADVAPL	DEG_SIAH_1	0.6028
p.A12T	ACH-001703	Lymphoma	CCLE	CPFADVAPL	DEG_SIAH_1	0.6028
p.A12T	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	CPFADVAPL	DEG_SIAH_1	0.6028
p.P7S	SIDM00808	Burkitt's Lymphoma	GDSC	CPFADVAPL	DEG_SIAH_1	0.6752
p.P7S	ACH-000707	Lymphoma	CCLE	CPFADVAPL	DEG_SIAH_1	0.6752
p.L14P	ACH-000449	Sarcoma	CCLE	CPFADVAPL	DEG_SIAH_1	0.7582
p.S5I	ACH-000702	Lymphoma	CCLE	CPFADVAPL	DEG_SIAH_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15304	Apoptosis regulatory protein Siva	DEG_SIAH_1	6:14	CPFADVAPL	SIAH1,SIAH2,SIAH3	0.647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons