DegronMD

Uniprot ID: Q8N6C5

Source protein: Immunoglobulin superfamily member 1

Source gene: IGSF1

Class: DEG_APCC_DBOX_1

Location: 1183:1191

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7292

ASA_SCORE: 53.2667

COIL: 0.5836

CONS_SCORE: 0.6075

DSS_SCORE: 0.3552

HELIX: 0.0072

FCONS_SCORE: 0.9783

RIG_SCORE: 0.7419

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1190V	TCGA-44-3398	LUAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.7532
p.D1183Y	TCGA-56-8624	LUSC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.7325
p.G1194D	TCGA-78-7153	LUAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.25
p.K1179R	TCGA-AA-3684	COAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.2222
p.G1194C	TCGA-AX-A063	UCEC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.25
p.E1196K	TCGA-BF-AAP4	SKCM	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.1944
p.I1184V	TCGA-BR-4256	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.7076
p.P1191T	TCGA-BR-7703	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.7031
p.K1179M	TCGA-BR-7704	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.2222
p.L1199V	TCGA-DX-A6YQ	SARC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.1111
p.F1178L	TCGA-DX-A6YQ	SARC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.1944
p.G1190E	TCGA-EE-A20C	SKCM	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	0.7199
p.S1197L	DO51862	BLCA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1667
p.R1175Q	DO228483	BRCA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1111
p.R1175Q	DO229489	LAML	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1111
p.E1198K	DO24920	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.G1180D	DO26347	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.25
p.G1176V	DO25030	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.G1189V	DO45461	LUSC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.6421
p.G1176E	DO222775	MELA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.G1176E	DO47665	SKCM	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.L1185V	DO220002	SARC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.6765
p.E1182K	DO219468	SKCM	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.3056
p.P1177T	DO38232	STAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.G1180C	DO42201	UCEC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.25
p.D1201Y	DO41488	UCEC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	0.0556
p.R1189Q	SIDM01151	Hepatocellular Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00304	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00496	Thyroid Gland Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM01145	Gastric Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00568	Gastric Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00556	Neuroblastoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00817	Kidney Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00177	Melanoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00026	Other Solid Cancers	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM01608	Endometrial Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM01526	Mesothelioma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM01448	Head and Neck Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM01413	Oral Cavity Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.R1189Q	SIDM00162	Biliary Tract Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7329
p.P1174S	SIDM00881	Breast Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1944
p.P1174S	HCC1428	breast	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1944
p.P1191L	SIDM01051	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7582
p.P1191L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7582
p.V1198F	SIDM00861	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.V1198F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1389
p.V1193F	ACH-000906	Ovarian Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.V1193F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.G1200E	ACH-001550	Skin Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	0.0833
p.G1200E	MCC13	skin	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.0833
p.P1193T	ACH-002198	Gastric Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.P1193T	SCH	stomach	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.D1188G	ACH-002227	Brain Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	0.7198
p.D1188G	D-392MG	central_nervous_system	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7198
p.V1184F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.7068
p.P1177L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.2778
p.D1197G	D-392MG	central_nervous_system	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.1667
p.P1186L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRGPLPGVE

Degron related mutations and impact score

Drug responses associated with IGSF1 mutations

All proteins holding degron of CRGPLPGVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6C5	Immunoglobulin superfamily member 1	DEG_APCC_DBOX_1	1183:1191	CRGPLPGVE	APC,CDC20,FZR1	0.7292	More...