DegronMD - Q8N6C5(IGSF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1320S	TCGA-13-1482	OV	TCGA	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.6993
p.G1190V	TCGA-44-3398	LUAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7532
p.D1183Y	TCGA-56-8624	LUSC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7325
p.G1194D	TCGA-78-7153	LUAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.25
p.K1179R	TCGA-AA-3684	COAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2222
p.E1316D	TCGA-AG-A008	READ	TCGA	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.6758
p.R1332I	TCGA-AN-A046	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.1389
p.R1332I	SIDM01043	Other Sarcomas	GDSC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.1389
p.R1332I	ESS-1	endometrium	COSMIC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.1389
p.G1194C	TCGA-AX-A063	UCEC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.25
p.N1324D	TCGA-AX-A2HJ	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation altering degron motif	0.6932
p.E1196K	TCGA-BF-AAP4	SKCM	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1944
p.I1184V	TCGA-BR-4256	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7076
p.P1191T	TCGA-BR-7703	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7031
p.K1179M	TCGA-BR-7704	STAD	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2222
p.D1305N	TCGA-D3-A8GC	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.0833
p.L1199V	TCGA-DX-A6YQ	SARC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1111
p.F1178L	TCGA-DX-A6YQ	SARC	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1944
p.G1190E	TCGA-EE-A20C	SKCM	TCGA	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7199
p.R1332K	TCGA-EY-A1G8	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.1389
p.E1316K	TCGA-FW-A3R5	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.7022
p.Q1331H	TCGA-G2-AA3B	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.1667
p.P1326L	TCGA-XV-AAZW	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.1667
p.P1326L	TCGA-XV-AAZW	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.3056
p.Q1317H	DO51882	BLCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.7582
p.S1197L	DO51862	BLCA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1667
p.R1175Q	DO228483	BRCA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1111
p.R1175Q	DO229489	LAML	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1111
p.R1318I	DO1285	BRCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.8102
p.R1318I	ACH-000913	Endometrial/Uterine Cancer	CCLE	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.8102
p.R1318I	ESS-1	endometrium	COSMIC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.8102
p.V1325I	DO10132	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation altering degron motif	0.7076
p.V1325I	DO18056	KIRC	ICGC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation altering degron motif	0.7076
p.E1198K	DO24920	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.G1180D	DO26347	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.25
p.G1176V	DO25030	LUAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.G1189V	DO45461	LUSC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.6421
p.S1314L	DO220906	MELA	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.7667
p.G1176E	DO222775	MELA	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.G1176E	DO47665	SKCM	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.G1306S	DO27977	OV	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.1111
p.L1185V	DO220002	SARC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.6765
p.I1319F	DO218847	SKCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.7415
p.E1322K	DO51281	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation altering degron motif	0.7022
p.P1312L	DO219495	SKCM	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.2778
p.P1312L	DO219495	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.0833
p.E1182K	DO219468	SKCM	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.3056
p.P1177T	DO38232	STAD	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation substituting flanking lysine	0.2778
p.N1310D	DO42105	UCEC	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.2222
p.G1180C	DO42201	UCEC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.25
p.R1318K	DO43578	UCEC	ICGC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation altering degron motif	0.7237
p.D1201Y	DO41488	UCEC	ICGC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.0556
p.P1324L	DO41361	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation altering degron motif	0.7582
p.A1309S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.1944
p.A1309S	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.1944
p.R1189Q	SIDM01151	Hepatocellular Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00304	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00496	Thyroid Gland Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM01145	Gastric Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00568	Gastric Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00556	Neuroblastoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00817	Kidney Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00177	Melanoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00026	Other Solid Cancers	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM01608	Endometrial Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM01526	Mesothelioma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM01448	Head and Neck Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM01413	Oral Cavity Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.R1189Q	SIDM00162	Biliary Tract Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7329
p.P1174S	SIDM00881	Breast Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation substituting flanking lysine	0.1944
p.P1174S	HCC1428	breast	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation substituting flanking lysine	0.1944
p.P1191L	SIDM01051	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7582
p.P1191L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7582
p.V1198F	SIDM00861	Ovarian Carcinoma	GDSC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.V1198F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1389
p.A1304S	ACH-000636	Leukemia	CCLE	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.0556
p.A1304S	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.0556
p.V1193F	ACH-000906	Ovarian Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2778
p.V1193F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2778
p.G1200E	ACH-001550	Skin Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.0833
p.G1200E	MCC13	skin	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.0833
p.P1193T	ACH-002198	Gastric Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2778
p.P1193T	SCH	stomach	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.2778
p.D1188G	ACH-002227	Brain Cancer	CCLE	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7198
p.D1188G	D-392MG	central nervous system	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7198
p.V1184F	ES-2	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.7068
p.P1177L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation substituting flanking lysine	0.2778
p.D1197G	D-392MG	central nervous system	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation rewiring degron network	0.1667
p.P1186L	EFO-27	ovary	COSMIC	CRGPLPGVE	DEG_APCC_DBOX_1	1183:1191	Mutation altering degron motif	0.6471
p.R1327I	ESS-1	endometrium	COSMIC	PGTPANS	DEG_SCF_FBW7_1	1314:1320	Mutation rewiring degron network	0.1389
p.R1327I	ESS-1	endometrium	COSMIC	PSSTS	DEG_SPOP_SBC_1	1321:1325	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF1

UniProt ID: Q8N6C5

Entrez ID: 3547

Protein name: Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF1 in