DegronMD

Uniprot ID: Q8N6C5

Source protein: Immunoglobulin superfamily member 1

Source gene: IGSF1

Class: DEG_SCF_FBW7_1

Location: 1314:1320

E3 ligase: FBXW7

DEGRON score: 0.6639

ASA_SCORE: 73.8714

COIL: 0.9281

CONS_SCORE: 0.6262

DSS_SCORE: 0.7889

HELIX: 0.0174

FCONS_SCORE: 1.0453

RIG_SCORE: 0.5513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1320S	TCGA-13-1482	OV	TCGA	PGTPANS	DEG_SCF_FBW7_1	0.6993
p.E1316D	TCGA-AG-A008	READ	TCGA	PGTPANS	DEG_SCF_FBW7_1	0.6758
p.D1305N	TCGA-D3-A8GC	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	0.0833
p.E1316K	TCGA-FW-A3R5	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	0.7022
p.P1326L	TCGA-XV-AAZW	SKCM	TCGA	PGTPANS	DEG_SCF_FBW7_1	0.1667
p.Q1317H	DO51882	BLCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.7582
p.R1318I	DO1285	BRCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.8102
p.R1318I	ACH-000913	Endometrial/Uterine Cancer	CCLE	PGTPANS	DEG_SCF_FBW7_1	0.8102
p.R1318I	ESS-1	endometrium	COSMIC	PGTPANS	DEG_SCF_FBW7_1	0.8102
p.S1314L	DO220906	MELA	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.7667
p.G1306S	DO27977	OV	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.1111
p.I1319F	DO218847	SKCA	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.7415
p.P1312L	DO219495	SKCM	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.2778
p.N1310D	DO42105	UCEC	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.2222
p.R1318K	DO43578	UCEC	ICGC	PGTPANS	DEG_SCF_FBW7_1	0.7237
p.A1309S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PGTPANS	DEG_SCF_FBW7_1	0.1944
p.A1309S	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPANS	DEG_SCF_FBW7_1	0.1944
p.A1304S	ACH-000636	Leukemia	CCLE	PGTPANS	DEG_SCF_FBW7_1	0.0556
p.A1304S	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPANS	DEG_SCF_FBW7_1	0.0556
p.R1327I	ESS-1	endometrium	COSMIC	PGTPANS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6C5	Immunoglobulin superfamily member 1	DEG_SCF_FBW7_1	1314:1320	PGTPANS	FBXW7	0.6639	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons