DegronMD

Uniprot ID: Q8N6U8

Source protein: G-protein coupled receptor 161

Source gene: GPR161

Class: DEG_APCC_DBOX_1

Location: 9:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8531

ASA_SCORE: 78.1444

COIL: 0.7076

CONS_SCORE: 0.3535

DSS_SCORE: 0.352

HELIX: 0.2003

FCONS_SCORE: 1.0741

RIG_SCORE: 0.7668

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16Q	TCGA-25-2399	OV	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	TCGA-BG-A0W2	UCEC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	TCGA-XF-AAML	BLCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO51933	BLCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO29206	OV	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO42624	UCEC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16L	TCGA-A8-A06Q	BRCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.8428
p.R16L	DO1263	BRCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.8428
p.T13N	TCGA-XR-A8TC	LIHC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7055
p.T13N	DO223920	LIHC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7055
p.E23K	DO49929	CESC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.1667
p.V26I	DO10108	COAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.0833
p.V26I	DO234278	ESAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.0833
p.E18D	DO7934	COAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Q8K	DO231984	LICA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.I27F	DO49876	LUAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.0556
p.V7I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00969	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00690	Head and Neck Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00854	Burkitt's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00032	Bladder Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM01445	Gastric Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.N24H	SIDM00193	Colorectal Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.1389
p.N24H	SNU-81	large_intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.1389
p.Q8H	SIDM00151	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Q8H	IGROV-1	ovary	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Y3H	ACH-000141	Gallbladder Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	0.1667
p.M14V	ACH-000988	Endometrial/Uterine Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	0.7208
p.M14V	MFE-319	endometrium	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.7208
p.N4H	ACH-000991	Colon/Colorectal Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	0.1944
p.N4H	SNU-81	large_intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.1944
p.L16Q	SK-MEL-31	skin	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.7765
p.L19Q	SK-MEL-31	skin	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.Q5H	IGROV-1	ovary	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.2222
p.N21H	SNU-81	large_intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.2222
p.L16M	CW-2	large_intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.5999

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRKELSNLT

Degron related mutations and impact score

Drug responses associated with GPR161 mutations

All proteins holding degron of CRKELSNLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6U8	G-protein coupled receptor 161	DEG_APCC_DBOX_1	9:17	CRKELSNLT	APC,CDC20,FZR1	0.8531	More...