DegronMD

Uniprot ID: Q8N6U8

Source protein: G-protein coupled receptor 161

Source gene: GPR161

Class: DEG_APCC_DBOX_1

Location: 9:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8531

ASA_SCORE: 78.1444

COIL: 0.7076

CONS_SCORE: 0.3535

DSS_SCORE: 0.352

HELIX: 0.2003

FCONS_SCORE: 1.0741

RIG_SCORE: 0.7668

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16L	TCGA-A8-A06Q	BRCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.8428
p.R16L	DO1263	BRCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.8428
p.L16Q	SK-MEL-31	skin	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.7765
p.R16Q	TCGA-25-2399	OV	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	TCGA-BG-A0W2	UCEC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	TCGA-XF-AAML	BLCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO51933	BLCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO29206	OV	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO42624	UCEC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7329
p.M14V	ACH-000988	Endometrial/Uterine Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	0.7208
p.M14V	MFE-319	endometrium	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.7208
p.T13N	TCGA-XR-A8TC	LIHC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	0.7055
p.T13N	DO223920	LIHC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.7055
p.L16M	CW-2	large_intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.5999
p.E18D	DO7934	COAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Q8K	DO231984	LICA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Q8H	SIDM00151	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.Q8H	IGROV-1	ovary	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	0.3056
p.V7I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00969	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00690	Head and Neck Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00854	Burkitt's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM00032	Bladder Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778
p.V7I	SIDM01445	Gastric Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	0.2778

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Drug responses associated with GPR161 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of CRKELSNLT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6U8	G-protein coupled receptor 161	DEG_APCC_DBOX_1	9:17	CRKELSNLT	APC,CDC20,FZR1	0.8531	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRKELSNLT

Degron related mutations and impact score

Drug responses associated with GPR161 mutations

All proteins holding degron of CRKELSNLT