DegronMD - Q8N6U8(GPR161)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R16Q	TCGA-25-2399	OV	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.R16Q	TCGA-BG-A0W2	UCEC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.R16Q	TCGA-XF-AAML	BLCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.R16Q	DO51933	BLCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.R16Q	DO29206	OV	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.R16Q	DO42624	UCEC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.A483T	TCGA-2W-A8YY	CESC	TCGA	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation rewiring degron network	0.2778
p.A483T	TCGA-2W-A8YY	CESC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation rewiring degron network	0.2778
p.A483T	SIDM00217	Colorectal Carcinoma	GDSC	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation rewiring degron network	0.2778
p.A483T	SIDM00217	Colorectal Carcinoma	GDSC	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation rewiring degron network	0.2778
p.A483T	SNU-1040	large intestine	COSMIC	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation rewiring degron network	0.2778
p.A483T	SNU-1040	large intestine	COSMIC	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation rewiring degron network	0.2778
p.V475A	TCGA-66-2767	LUSC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation altering degron motif	0.6936
p.E502K	TCGA-95-7043	LUAD	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.0833
p.R16L	TCGA-A8-A06Q	BRCA	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.8428
p.R16L	DO1263	BRCA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.8428
p.A503T	TCGA-B5-A3FC	UCEC	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1111
p.K465N	TCGA-CA-6718	COAD	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation rewiring degron network	0.0556
p.S525G	TCGA-CG-5728	STAD	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1667
p.L479S	TCGA-DF-A2KN	UCEC	TCGA	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation altering degron motif	0.7667
p.L479S	TCGA-DF-A2KN	UCEC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation altering degron motif	0.7667
p.G516E	TCGA-EE-A2MJ	SKCM	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.7199
p.G521D	TCGA-FI-A2CY	UCEC	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.2778
p.A489S	TCGA-VQ-A8P2	STAD	TCGA	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation rewiring degron network	0.1111
p.A489S	TCGA-VQ-A8P2	STAD	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation rewiring degron network	0.1111
p.T13N	TCGA-XR-A8TC	LIHC	TCGA	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7055
p.T13N	DO223920	LIHC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7055
p.E23K	DO49929	CESC	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1667
p.V26I	DO10108	COAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.0833
p.V26I	DO234278	ESAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.0833
p.E18D	DO7934	COAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.3056
p.Q8K	DO231984	LICA	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.3056
p.I27F	DO49876	LUAD	ICGC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.0556
p.V7I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM00969	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM00690	Head and Neck Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM00854	Burkitt's Lymphoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM00032	Bladder Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V7I	SIDM01445	Gastric Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.G518S	SIDM01237	Hepatocellular Carcinoma	GDSC	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.6993
p.G518S	C3A	liver	COSMIC	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.6993
p.N24H	SIDM00193	Colorectal Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1389
p.N24H	SNU-81	large intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1389
p.Q8H	SIDM00151	Ovarian Carcinoma	GDSC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.3056
p.Q8H	IGROV-1	ovary	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.3056
p.Y3H	ACH-000141	Gallbladder Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1667
p.M14V	ACH-000988	Endometrial/Uterine Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7208
p.M14V	MFE-319	endometrium	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7208
p.N4H	ACH-000991	Colon/Colorectal Cancer	CCLE	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1944
p.N4H	SNU-81	large intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1944
p.L16Q	SK-MEL-31	skin	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7765
p.L19Q	SK-MEL-31	skin	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.G515S	C3A	liver	COSMIC	QRLQLQSIE	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.6993
p.Q5H	IGROV-1	ovary	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2222
p.N21H	SNU-81	large intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2222
p.L16M	CW-2	large intestine	COSMIC	CRKELSNLT	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.5999
p.A480T	SNU-1040	large intestine	COSMIC	INLFGE	LIG_APCC_ABBA_1	476:481	Mutation altering degron motif	0.7139
p.A480T	SNU-1040	large intestine	COSMIC	KINLFGE	LIG_APCC_ABBAyCdc20_2	475:481	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR161

UniProt ID: Q8N6U8

Entrez ID: 23432

Protein name: G-protein coupled receptor 161 (G-protein coupled receptor RE2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR161 in