DegronMD

Uniprot ID: Q8N6U8

Source protein: G-protein coupled receptor 161

Source gene: GPR161

Class: DEG_APCC_DBOX_1

Location: 511:519

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.963

ASA_SCORE: 97.2556

COIL: 0.5652

CONS_SCORE: 0.4617

DSS_SCORE: 0.3538

HELIX: 0.1504

FCONS_SCORE: 1.4086

RIG_SCORE: 0.7948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E502K	TCGA-95-7043	LUAD	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	0.0833
p.A503T	TCGA-B5-A3FC	UCEC	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	0.1111
p.S525G	TCGA-CG-5728	STAD	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	0.1667
p.G516E	TCGA-EE-A2MJ	SKCM	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	0.7199
p.G521D	TCGA-FI-A2CY	UCEC	TCGA	QRLQLQSIE	DEG_APCC_DBOX_1	0.2778
p.G518S	SIDM01237	Hepatocellular Carcinoma	GDSC	QRLQLQSIE	DEG_APCC_DBOX_1	0.6993
p.G518S	C3A	liver	COSMIC	QRLQLQSIE	DEG_APCC_DBOX_1	0.6993
p.G515S	C3A	liver	COSMIC	QRLQLQSIE	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6U8	G-protein coupled receptor 161	DEG_APCC_DBOX_1	511:519	QRLQLQSIE	APC,CDC20,FZR1	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons