DegronMD

Uniprot ID: Q8N6U8

Source protein: G-protein coupled receptor 161

Source gene: GPR161

Class: LIG_APCC_ABBAyCdc20_2

Location: 475:481

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8155

ASA_SCORE: 78.6

COIL: 0.6323

CONS_SCORE: 0.424

DSS_SCORE: 0.1133

HELIX: 0.1733

FCONS_SCORE: 1.2275

RIG_SCORE: 0.8329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A483T	TCGA-2W-A8YY	CESC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A483T	SIDM00217	Colorectal Carcinoma	GDSC	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A483T	SNU-1040	large_intestine	COSMIC	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V475A	TCGA-66-2767	LUSC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.6936
p.K465N	TCGA-CA-6718	COAD	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L479S	TCGA-DF-A2KN	UCEC	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.7667
p.A489S	TCGA-VQ-A8P2	STAD	TCGA	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A480T	SNU-1040	large_intestine	COSMIC	KINLFGE	LIG_APCC_ABBAyCdc20_2	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6U8	G-protein coupled receptor 161	LIG_APCC_ABBAyCdc20_2	475:481	KINLFGE	APC,CDC20,FZR1	0.8155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons