DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
INLFGE
Uniprot ID:
Q8N6U8
Source protein:
G-protein coupled receptor 161
Source gene:
GPR161
Class:
LIG_APCC_ABBA_1
Location:
476:481
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7351
ASA_SCORE:
69.6
COIL:
0.6315
CONS_SCORE:
0.4245
DSS_SCORE:
0.1121
HELIX:
0.1595
FCONS_SCORE:
1.2117
RIG_SCORE:
0.8278
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A483T
TCGA-2W-A8YY
CESC
TCGA
INLFGE
LIG_APCC_ABBA_1
0.2778
p.A483T
SIDM00217
Colorectal Carcinoma
GDSC
INLFGE
LIG_APCC_ABBA_1
0.2778
p.A483T
SNU-1040
large_intestine
COSMIC
INLFGE
LIG_APCC_ABBA_1
0.2778
p.L479S
TCGA-DF-A2KN
UCEC
TCGA
INLFGE
LIG_APCC_ABBA_1
0.7667
p.A489S
TCGA-VQ-A8P2
STAD
TCGA
INLFGE
LIG_APCC_ABBA_1
0.1111
p.A480T
SNU-1040
large_intestine
COSMIC
INLFGE
LIG_APCC_ABBA_1
0.7139
Drug responses associated with GPR161 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of INLFGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N6U8
G-protein coupled receptor 161
LIG_APCC_ABBA_1
476:481
INLFGE
APC,CDC20,FZR1
0.7351
More...