DegronMD

Uniprot ID: Q3SX64

Source protein: Outer dense fiber protein 3-like protein 2

Source gene: ODF3L2

Class: DEG_APCC_DBOX_1

Location: 147:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 67.7778

COIL: 0.8163

CONS_SCORE: 0.6007

DSS_SCORE: 0.4335

HELIX: 0.0594

FCONS_SCORE: 0.8506

RIG_SCORE: 0.7656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A160V	TCGA-BP-4161	KIRC	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	0.1944
p.A160V	DO17769	KIRC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.1944
p.A160V	DO229272	THCA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.1944
p.R148C	TCGA-CK-5913	COAD	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	0.8301
p.R148C	DO8826	COAD	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.8301
p.R148C	DO233898	GACA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.8301
p.L149F	TCGA-D1-A16F	UCEC	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	0.587
p.L149F	DO42408	UCEC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.587
p.P159H	DO233903	GACA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.2222
p.P140L	DO43418	UCEC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3SX64	Outer dense fiber protein 3-like protein 2	DEG_APCC_DBOX_1	147:155	CRLPLKPLD	APC,CDC20,FZR1	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons